血管内皮生长因子基因多态性与克里米亚-刚果出血热之间的关系
Relationship between vascular endothelial growth factor gene polymorphisms and Crimean-Congo hemorrhagic fever.
作者信息
Coşkun Umut Safiye Şay, Yiğit Serbülent, Aci Recai, Tural Ercan, Bozkurt Nihan, Barut Hüseyin Şener
机构信息
Tokat Gaziosmanpaşa University, Faculty of Medicine, Department of Medical Microbiology - Tokat, Türkiye.
Ondokuz Mayıs University, Faculty of Veterinary Medicine, Department of Genetics - Samsun, Türkiye.
出版信息
Rev Assoc Med Bras (1992). 2025 Aug 8;71(7):e20250147. doi: 10.1590/1806-9282.20250147. eCollection 2025.
OBJECTIVE
This study aims to investigate the relationship between vascular endothelial growth factor gene polymorphisms and Crimean-Congo hemorrhagic fever.
METHODS
A total of 130 serum samples were analyzed, including 60 patients diagnosed with Crimean-Congo hemorrhagic fever and 70 healthy controls. Genetic analyses were performed using polymerase chain reaction and restriction fragment length polymorphism techniques.
RESULTS
Significant differences were observed between patient and control groups in terms of vascular endothelial growth factor -460 C/T and -ID (18 bp) polymorphisms.
CONCLUSION
Vascular endothelial growth factor gene polymorphisms may contribute to genetic susceptibility to Crimean-Congo hemorrhagic fever. Further studies with larger sample sizes are recommended to support these findings.
目的
本研究旨在探讨血管内皮生长因子基因多态性与克里米亚-刚果出血热之间的关系。
方法
共分析了130份血清样本，其中包括60例诊断为克里米亚-刚果出血热的患者和70名健康对照。采用聚合酶链反应和限制性片段长度多态性技术进行基因分析。
结果
在血管内皮生长因子-460 C/T和-ID（18bp）多态性方面，患者组与对照组之间存在显著差异。
结论
血管内皮生长因子基因多态性可能导致对克里米亚-刚果出血热的遗传易感性。建议进行更大样本量的进一步研究以支持这些发现。
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