Ng Cheong Ton J M, Amit Z
Neurosci Lett. 1985 Oct 24;61(1-2):131-4. doi: 10.1016/0304-3940(85)90413-6.
The interaction between acetaldehyde, the primary metabolite of ethanol, and morphine was examined in the preexposure conditioned taste aversion (CTA) paradigm. Rats that were preexposed to acetaldehyde did not display a CTA to morphine. While acetaldehyde at the dose tested did not induce a strong CTA, morphine preexposure, however, reversed the decrease in saccharin associated with acetaldehyde injection thus reflecting a symmetrical interaction between acetaldehyde and morphine. Implications for a mechanism of ethanol-opiates interaction are discussed.
在预先暴露条件性味觉厌恶（CTA）范式中，研究了乙醇的主要代谢产物乙醛与吗啡之间的相互作用。预先暴露于乙醛的大鼠对吗啡未表现出条件性味觉厌恶。虽然所测试剂量的乙醛未诱导强烈的条件性味觉厌恶，但预先暴露于吗啡可逆转与注射乙醛相关的糖精摄入量减少，从而反映出乙醛与吗啡之间的对称相互作用。文中讨论了乙醇 - 阿片类药物相互作用机制的相关意义。
