Anand Akshatha, Nagarajappa Vani Hebbal, Palany Raghupathy
Indira Gandhi Institute of Child Health Division of Pediatric and Adolescent Endocrinology Bengaluru India Division of Pediatric and Adolescent Endocrinology, Indira Gandhi Institute of Child Health, Bengaluru, India.
Arch Endocrinol Metab. 2025 Aug 13;69(3). doi: 10.20945/2359-4292-2025-0017.
To identify early manifestations of Graves' disease in young patients and its treatment outcomes.
This was a hospital-based review of case records of 47 children (aged 1 month to 18 years) with Graves' disease from 2011 to 2022. Data were summarized and statistically analyzed.
This study included 47 patients with Graves' disease, of whom 31 (66%) were girls. The average age at the initial diagnosis was 12.79 ± 3.75 years. Common presenting complaints included heat intolerance (76.6%), excessive sweating (74.5%), palpitations (68.1%), tremors (48.9%), weight loss (38.3%), increased appetite (34%), diarrhea (31.9%), and constipation (4.3%). The mean thyrotropin receptor antibody titer was 16.93 ± 13.47 IU/L. Remission was achieved in two (4.3%) patients treated with antithyroid drugs.
Graves' disease is the most common cause of juvenile hyperthyroidism, and treating physicians should be aware of its signs and symptoms to avoid treatment delays.
确定年轻患者格雷夫斯病的早期表现及其治疗结果。
这是一项基于医院的回顾性研究，对2011年至2022年期间47例（年龄1个月至18岁）格雷夫斯病患儿的病例记录进行分析。对数据进行总结并进行统计学分析。
本研究纳入47例格雷夫斯病患者，其中31例（66%）为女孩。初次诊断时的平均年龄为12.79±3.75岁。常见的就诊主诉包括不耐热（76.6%）、多汗（74.5%）、心悸（68.1%）、震颤（48.9%）、体重减轻（38.3%）、食欲增加（34%）、腹泻（31.9%）和便秘（4.3%）。促甲状腺素受体抗体平均滴度为16.93±13.47IU/L。接受抗甲状腺药物治疗的患者中有2例（4.3%）实现缓解。
格雷夫斯病是青少年甲状腺功能亢进最常见的病因，治疗医生应了解其体征和症状，以避免治疗延误。
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