Janssen J T, Ludwig H, Scheithauer W, de Pauw B E, Keyser A, van Tol R, Flener R
Oncology. 1985;42 Suppl 1:3-6. doi: 10.1159/000226075.
Twenty-two patients with advanced haemopoietic and other malignancies were treated intramuscularly with recombinant interferon-alpha 2C in a daily escalating dose. The most common side-effects were flu-like symptoms. Two patients showed severe neurotoxicity, which was completely reversible in 1 case. Doses above 30 X 10(6) IU/day were poorly tolerated and could only be achieved in a minority of the patients. Objective tumour responses were documented in malignant lymphomas, hairy cell leukaemia, and renal cell carcinoma.
22例晚期造血系统恶性肿瘤及其他恶性肿瘤患者接受了重组干扰素α-2C肌肉注射治疗，剂量每日递增。最常见的副作用是流感样症状。2例患者出现严重神经毒性，其中1例完全可逆。每日剂量超过30×10⁶IU时耐受性较差，只有少数患者能够达到该剂量。在恶性淋巴瘤、毛细胞白血病和肾细胞癌中记录到了客观的肿瘤反应。
