Zhang Chen, Li Wenli, Fan Huiying, Niu Ming, Song Hao, Dong Huifang, Yan Qing, Xu Falin
Department of Neonatology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Henan Pediatric Clinical Research Center, Advanced Medical Research Center of Zhengzhou University, Zhengzhou, China.
Sci Rep. 2025 Aug 13;15(1):29700. doi: 10.1038/s41598-025-15667-5.
Cerebral blood flow (CBF) is crucial for supplying the brain with the oxygen and nutrients necessary for its proper development and metabolism. The poor autoregulation of CBF is believed to play a role in the development of brain injury in preterm infants. This study aimed to investigate the characteristics of CBF in perinatal brain injury. In this retrospective study, 108 healthy preterm infants (HP), 26 infants with intracranial hemorrhage (IVH), and 16 infants with periventricular leukomalacia (PVL) were included. CBF was assessed using arterial spin labeling imaging in the frontal, temporal, parietal, and occipital cortex, as well as the basal ganglia and thalamus. After adjusting for gestational age, postmenstrual age (PMA) at MRI scan, and birth weight, the PVL hemispheres exhibited consistently reduced CBF in various gray matter regions compared to the HP and IVH hemispheres, including the frontal, temporal, parietal, and occipital cortex, as well as the basal ganglia and thalamus. The comparison of HP and IVH hemispheres revealed decreased CBF in IVH hemispheres in the frontal, parietal, occipital cortex, as well as in the basal ganglia and thalamus. In multifactor linear regression models, the PMA at MRI scan, 5 min Apgar score, brain injury, and neonatal necrotizing stage ≥ 2 are independent factors affecting cerebral perfusion.
脑血流量（CBF）对于为大脑提供其正常发育和代谢所需的氧气和营养物质至关重要。CBF的自身调节功能不佳被认为在早产儿脑损伤的发生中起作用。本研究旨在调查围产期脑损伤中CBF的特征。在这项回顾性研究中，纳入了108名健康早产儿（HP）、26名颅内出血（IVH）婴儿和16名脑室周围白质软化（PVL）婴儿。使用动脉自旋标记成像对额叶、颞叶、顶叶和枕叶皮质以及基底神经节和丘脑的CBF进行评估。在调整了胎龄、MRI扫描时的月经后年龄（PMA）和出生体重后，与HP和IVH半球相比，PVL半球在各个灰质区域（包括额叶、颞叶、顶叶和枕叶皮质以及基底神经节和丘脑）的CBF持续降低。HP和IVH半球的比较显示，IVH半球在额叶、顶叶、枕叶皮质以及基底神经节和丘脑的CBF降低。在多因素线性回归模型中，MRI扫描时的PMA、5分钟阿氏评分、脑损伤以及新生儿坏死分期≥2是影响脑灌注的独立因素。
