Li Chengjun, Lu Hongrui, Chu Haorui, Peng Wei, Xu Meiling
Department of Neurology, Huangdao District Hospital of Traditional Chinese Medicine, Qingdao, China.
The Second Clinical School, Heilongjiang University of Traditional Chinese Medicine, Harbin, China.
Sci Rep. 2025 Aug 13;15(1):29747. doi: 10.1038/s41598-025-15369-y.
The association between inflammation and cardiovascular disease (CVD) is increasingly garnering attention. However, the association between neutrophil percentage to albumin ratio (NPAR) and CVD in the metabolic syndrome population remains unclear. Therefore, we employed a large-scale epidemiological database to investigate this association. Multivariable logistic regression models were used to examine the association between NPAR and CVD among people with metabolic syndrome. The potential nonlinearity was investigated by a restricted cubic spline. After detecting the nonlinearity, recursive algorithms were utilized to calculate the inflection point and effects before and after the point. Stratified analyses and interaction tests were employed to explore differences between subgroups. After adjusting for all covariates, NPAR was positively associated with CVD in the metabolic syndrome population [1.10 (1.05, 1.16)]. Subsequent analysis with restricted cubic splines revealed a nonlinear association between NPAR and CVD among adults with metabolic syndrome. A recursive algorithm identified an inflection point at 14.21. Only after this point, NPAR was positively correlated with CVD [1.12 (1.10, 1.15)]. In the subgroup analysis by sex and age, a linear association was found only in females, while others showed a nonlinear relationship. In conclusion, we observed a nonlinear relationship between NPAR and CVD in American metabolic syndrome population.
炎症与心血管疾病（CVD）之间的关联日益受到关注。然而，代谢综合征人群中中性粒细胞百分比与白蛋白比值（NPAR）和CVD之间的关联仍不清楚。因此，我们利用一个大规模的流行病学数据库来研究这种关联。多变量逻辑回归模型用于检验代谢综合征患者中NPAR与CVD之间的关联。通过受限立方样条研究潜在的非线性关系。在检测到非线性后，利用递归算法计算拐点以及该点前后的效应。采用分层分析和交互作用检验来探索亚组之间的差异。在对所有协变量进行调整后，代谢综合征人群中NPAR与CVD呈正相关[1.10（1.05，1.16）]。随后用受限立方样条进行的分析显示，代谢综合征成年人中NPAR与CVD之间存在非线性关联。递归算法确定的拐点为14.21。仅在该点之后，NPAR与CVD呈正相关[1.12（1.10，1.15）]。在按性别和年龄进行的亚组分析中，仅在女性中发现线性关联，而其他组呈现非线性关系。总之，我们观察到美国代谢综合征人群中NPAR与CVD之间存在非线性关系。
