Alwafi Hassan, Naser Abdallah Y, Alharbi Ranad, Tawakkul Sara, Albayhie Aseel, Alsaiari Wed, Aloqilyi Joud, Althagafi Layan, Aldhahiri Abdulelah M, Alqarni Abdullah A, Alqahtani Jaber S, Alghamdi Saeed M, Khan Saleha, Alsaggaf Hamza, Dairi Mohammad Saleh, Alsharif Alaa A
Department of Pharmacology and Toxicology, College of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia.
Department of Applied Pharmaceutical Sciences and Clinical Pharmacy, Faculty of Pharmacy, Isra University, Amman, Jordan.
Sci Rep. 2025 Aug 13;15(1):29758. doi: 10.1038/s41598-025-15070-0.
Nicotine pouches are becoming increasingly popular. However, there's still a lack of comprehensive data on how widespread nicotine pouch use and its side effects in Saudi Arabia. This study aims to investigate the prevalence and associated side effects of the use of nicotine pouches among smokers and the public in Saudi Arabia. This study also investigated their utilization in smoking cessation. This study used an online cross-sectional questionnaire-based design. The study population included individuals over the age of 18 living in Saudi Arabia. The questionnaire was distributed through social media platforms. Statistical analysis was conducted using SPSS software. Descriptive statistics were used to generate means and percentages. Regression analysis was performed to predict factors associated with the use of nicotine pouches for the purpose of smoking cessation. A total of 657 participants were included in the analysis. Regarding age distribution, the majority were aged between 18 and 30 years. Most participants were male (422; 64.2%). Regarding the prevalence of nicotine pouches use, (21.2%) had tried the pouches before. Among those who had used nicotine pouches, 57 participants (41.0%) reported success in quitting smoking, while 53 participants (38.1%) experienced only a little success, and 29 participants (20.9%) were unsuccessful. The most common adverse effect was nausea (88, 13.4%), followed by fatigue (44, 6.7%) and headache (43, 6.5%). Participants who smoked 4-6 cigarettes per day, 7-9 cigarettes per day, or more than 10 cigarettes per day had higher odds of nicotine pouch use (OR = 3.70,95% CI = 1.14-11.96, p = 0.02), (OR = 6.74,95% CI = 1.71-26.5, p = 0.006) and (OR = 2.59,95% CI = 1.07-6.26, p = 0.03). This study showed a promising result of the use of nicotine pouches and success in quitting smoking in Saudi Arabia population. Most of the side effects reported in the study were mild. However, future studies with larger sample size and analytical design are needed.
尼古丁袋正变得越来越受欢迎。然而，在沙特阿拉伯，关于尼古丁袋的使用范围及其副作用，仍然缺乏全面的数据。本研究旨在调查沙特阿拉伯吸烟者和公众中使用尼古丁袋的患病率及其相关副作用。本研究还调查了它们在戒烟中的应用。本研究采用基于在线横断面问卷调查的设计。研究人群包括居住在沙特阿拉伯的18岁以上个体。问卷通过社交媒体平台分发。使用SPSS软件进行统计分析。描述性统计用于生成均值和百分比。进行回归分析以预测与为戒烟目的使用尼古丁袋相关的因素。共有657名参与者纳入分析。关于年龄分布，大多数人年龄在18至30岁之间。大多数参与者为男性（422人；64.2%）。关于尼古丁袋的使用患病率，（21.2%）的人以前尝试过使用尼古丁袋。在使用过尼古丁袋的人中，57名参与者（41.0%）报告戒烟成功，而53名参与者（38.1%）仅取得了一点成功，29名参与者（20.9%）未成功。最常见的副作用是恶心（88例，13.4%），其次是疲劳（44例，6.7%）和头痛（43例，6.5%）。每天吸4 - 6支烟、7 - 9支烟或超过10支烟的参与者使用尼古丁袋的几率更高（OR = 3.70，95%CI = 1.14 - 11.96，p = 0.02），（OR = 6.74，95%CI = 1.71 - 26.5，p = 0.006）和（OR = 2.59，95%CI = 1.07 - 6.26，p = 0.03）。本研究显示了在沙特阿拉伯人群中使用尼古丁袋及戒烟成功的有前景的结果。研究中报告的大多数副作用是轻微的。然而，需要未来进行更大样本量和分析设计的研究。
