Liu Yao, Wang Lin
Central Hospital of Dalian University of Technology (Dalian Municipal Central Hospital), Dalian, 116038, Liaoning, China.
Aesthetic Plast Surg. 2025 Aug 13. doi: 10.1007/s00266-025-04906-9.
This study examined the clinical efficacy of botulinum toxin type A (BTX-A) combined with non-cross-linked bovine collagen in improving periorbital wrinkles.
Forty participants with periorbital wrinkles were recruited from the Plastic Surgery and Aesthetic Department of the Central Hospital Affiliated to Dalian University of Technology in China between November 2021 and August 2022. Participants were randomly assigned to either an observation group or a control group, with each group comprising 20 participants. The control group received BTX-A injection alone, whereas the observation group received combined injections of BTX-A and collagen filler.
Standardized photographic images were taken at baseline and at 1-week, 1-month, 3-month, and 6-month follow-ups after the injection. The rejuvenation effect was evaluated using the 5-grade Wrinkle Severity Rating Scale, whereas patient satisfaction was assessed using the Global Aesthetic Improvement Scale. Both groups achieved a total effective rate of 100%. However, the markedly effective rate was significantly higher in the observation group (90%) than in the control group (40%; p < 0.01). Moreover, 95% patients in the observation group reported great satisfaction, and the percentage was significantly higher than that in the control group (20%; p < 0.01). No adverse events were reported during the study.
BTX-A injections combined with non-cross-linked bovine collagen filler provide a highly effective and safe therapy for improving periorbital wrinkles.
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本研究探讨A型肉毒毒素（BTX-A）联合非交联牛胶原蛋白改善眶周皱纹的临床疗效。
2021年11月至2022年8月期间，从中国大连理工大学附属中心医院整形美容科招募了40名有眶周皱纹的参与者。参与者被随机分为观察组和对照组，每组20名。对照组仅接受BTX-A注射，而观察组接受BTX-A和胶原蛋白填充剂联合注射。
在注射前的基线以及注射后1周、1个月、3个月和6个月随访时拍摄标准化照片。使用5级皱纹严重程度评定量表评估年轻化效果，而使用全球美容改善量表评估患者满意度。两组的总有效率均达到100%。然而，观察组的显效率（90%）显著高于对照组（40%；p<0.01）。此外，观察组95%的患者表示非常满意，该百分比显著高于对照组（20%；p<0.01）。研究期间未报告不良事件。
BTX-A注射联合非交联牛胶原蛋白填充剂为改善眶周皱纹提供了一种高效且安全的治疗方法。
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