Liu Pengran, Mao Limei, Wang Bangyue, Guo Jing, Dai Hui, Zhao Yan, Yin Hao, Zhu Xihai, Dong Wentao, Liu Shujie, Yang Xinyu, Zhang Xiaojun
Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China.
Department of Geriatrics, Liao cheng People's Hospital, Liaocheng, Shandong, China.
BMC Neurol. 2025 Aug 13;25(1):337. doi: 10.1186/s12883-025-04362-7.
Intracranial aneurysms combined with spontaneous internal carotid artery occlusion (ICAO) are a rare and serious vascular disorder. Currently, there is only limited information available on the clinical characteristics of these patients and the risk factors for aneurysm rupture. Our objective is to describe the clinical features of these patients and predict the risk factors for the rupture of unruptured intracranial aneurysms (UIAs) combined with ICAO.
We retrospectively analyzed cases of intracranial aneurysms with concurrent spontaneous ICAO from the Chinese Multicenter Aneurysm Database(CMAD). We collected population demographic characteristics and clinical data using a standardized case questionnaire from CMAD. Binary logistic regression analysis was used to identify risk factors for rupture of UIA associated with combined ICAO.
We identified 93 patients with intracranial aneurysms combined with ICAO, including 38 females and 55 males, with an average age of 60.7 ± 9.5 years (ranging from 32 to 79 years old). Among those with ICAO, 52 had ruptured intracranial aneurysms (RIAs) and 41 had UIAs. Specifically, there were 81 cases of unilateral ICAO, with 16 aneurysms located on the same side as the ICAO, 22 in the midline (AcomA, Basilar tip), and 43 on the opposite side of the ICAO; 12 cases were bilateral ICAO. Binary logistic regression analysis indicated that risk factors associated with the rupture of UIAs with ICAO included bilateral internal carotid artery occlusion and aneurysms in the posterior circulation. Furthermore, multivariate analysis showed that posterior circulation aneurysms are an independent risk factor for the rupture of UIAs with ICAO.
We have described and analyzed the clinical characteristics and risk factors influencing the rupture of intracranial aneurysms in patients with ICAO. The study found that the location of the aneurysm is an important risk factor for the rupture of UIAs combined with ICAO.
颅内动脉瘤合并自发性颈内动脉闭塞（ICAO）是一种罕见且严重的血管疾病。目前，关于这些患者的临床特征以及动脉瘤破裂的危险因素的信息有限。我们的目的是描述这些患者的临床特征，并预测未破裂颅内动脉瘤（UIA）合并ICAO破裂的危险因素。
我们回顾性分析了来自中国多中心动脉瘤数据库（CMAD）的颅内动脉瘤并发自发性ICAO的病例。我们使用CMAD的标准化病例问卷收集了人口统计学特征和临床数据。采用二元逻辑回归分析来确定与合并ICAO相关的UIA破裂的危险因素。
我们确定了93例颅内动脉瘤合并ICAO的患者，其中女性38例，男性55例，平均年龄为60.7±9.5岁（范围为32至79岁）。在ICAO患者中，52例为颅内动脉瘤破裂（RIA），41例为UIA。具体而言，单侧ICAO有81例，其中16个动脉瘤位于与ICAO同侧，22个位于中线（前交通动脉、基底动脉尖），43个位于ICAO对侧；双侧ICAO有12例。二元逻辑回归分析表明，与合并ICAO的UIA破裂相关的危险因素包括双侧颈内动脉闭塞和后循环动脉瘤。此外，多变量分析显示后循环动脉瘤是合并ICAO的UIA破裂的独立危险因素。
我们描述并分析了ICAO患者颅内动脉瘤破裂的临床特征和影响因素。研究发现，动脉瘤的位置是合并ICAO的UIA破裂的重要危险因素。
