Axier Aximujiang, Rexiati Nizamidingjiang, Wang Zengliang, Cheng Xiaojiang, Su Riqing, Aikeremu Rexidan, Aisha Maimaitili
Department of Neurosurgery, The First Affiliated Hospital of Xinjiang Medical University Urumqi 830054, Xinjiang, China.
Department of Medical Record Management, The First Affiliated Hospital of Xinjiang Medical University Urumqi 830054, Xinjiang, China.
Am J Transl Res. 2022 Jul 15;14(7):4638-4647. eCollection 2022.
In this study, the hemodynamic parameters of ruptured intracranial aneurysms (IAs) in various studies were summarized and analyzed to provide predictive parameters for IA rupture in clinical work.
We searched PubMed, Web of science, Embase, and Cochrane databases for articles published before December 2021 to collect data on hemodynamic parameters associated with IA rupture. Differences in wall shear stress (WSS), oscillatory shear index (OSI), and low wall shear stress area (LSA) between ruptured and unruptured IAs in the literature were summarized and analyzed, and the standardized mean difference (SMD) of 95% CI was calculated by Review Manager 5.3.
By searching and screening the literature, this meta-analysis included 17 studies comprising 1,373 IA patients. In the ruptured aneurysm group, the level of WSS decreased significantly, while OSI and LSA increased obviously.
Low WSS, high OSI, and high LSA are closely related to the rupture of IAs, indicating the role of WSS, OSI, and LSA as important hemodynamic parameters for predicting the rupture of IAs in clinical work.
本研究对各项研究中破裂颅内动脉瘤（IA）的血流动力学参数进行总结分析，为临床工作中IA破裂提供预测参数。
检索PubMed、Web of科学、Embase和Cochrane数据库中2021年12月以前发表的文章，收集与IA破裂相关的血流动力学参数数据。总结分析文献中破裂与未破裂IA之间壁面剪应力（WSS）、振荡剪切指数（OSI）和低壁面剪应力面积（LSA）的差异，采用Review Manager 5.3计算95%CI的标准化均数差（SMD）。
通过文献检索和筛选，本荟萃分析纳入17项研究，共1373例IA患者。在破裂动脉瘤组中，WSS水平显著降低，而OSI和LSA明显升高。
低WSS、高OSI和高LSA与IA破裂密切相关，表明WSS、OSI和LSA在临床工作中作为预测IA破裂的重要血流动力学参数的作用。
