Sann L, Baltassat P, You J E, Simonnet C, Bethenod M
Pediatrie. 1985 Jun;40(4):267-76.
The aim of this study was to evaluate the influence of an hyperosmolar solution of theophylline and of blood transfusion in the occurrence of necrotizing enterocolitis (NEC). By the end of 1982, theophylline previously given in alcoholic solution (osmolality greater than 4000 mosm/kg) was given in a preparation of sodium benzoate isoosmotic to the plasma; in addition, blood was irradiated for 20 minutes by X-Rays (5000 rads) before every transfusion. In the same unit of premature infants, the incidence of NEC was 6.7% in 1981-82; it decreased to 2.7% in 1983-84 (p less than 0.02). In the same periods of time, the incidence of NEC in very low birth weight infants (less than 1500 g) decreased from 18% to 4.7% (p less than 0.001) while the number of these very low birth weight infants had increased significantly. The incidence of blood transfusion prior to NEC was found in 67% of the patients. These data suggest a beneficial role of reducing the osmolality of theophylline and of X-Rays irradiation of blood before transfusion as a prophylaxis of NEC in premature infants.
本研究的目的是评估茶碱高渗溶液和输血对坏死性小肠结肠炎（NEC）发生的影响。到1982年底，以前以酒精溶液形式给予的茶碱（渗透压大于4000 mosm/kg）改为以与血浆等渗的苯甲酸钠制剂形式给予；此外，每次输血前，血液用X射线照射20分钟（5000拉德）。在同一组早产儿中，1981 - 1982年NEC的发生率为6.7%；1983 - 1984年降至2.7%（p小于0.02）。在相同时间段内，极低出生体重儿（小于1500克）中NEC的发生率从18%降至4.7%（p小于0.001），而这些极低出生体重儿的数量显著增加。在67%的NEC患者中发现有输血史。这些数据表明，降低茶碱的渗透压以及输血前对血液进行X射线照射对预防早产儿NEC具有有益作用。
