Bult A, Dingjan H A, Dreijer-van der Glas S M, Van Bennekom W P
Pharm Weekbl Sci. 1985 Dec 13;7(6):267-72. doi: 10.1007/BF01959200.
For the two-phase titration based on ion-pair and metal-complex formation full attention is given to side reactions in both phases. Their significance for the applicability of this type of titration is evaluated. Side reactions in the aqueous phase diminish and in the organic phase promote the 'titratability'. Equations for the calculation of the side reaction coefficients, the titration curve and the selection of the optimal pH and minimal side reaction interference (in the aqueous phase) are presented. Finally a full description is given of the two-phase titration including all parameters determining the 'titratability'. The merits of the developed theory are illustrated by literature examples.
对于基于离子对和金属配合物形成的两相滴定，需充分关注两相中的副反应。评估了它们对这类滴定适用性的重要性。水相中的副反应会降低“可滴定性”，而有机相中的副反应则会促进“可滴定性”。给出了计算副反应系数、滴定曲线以及选择最佳pH值和最小副反应干扰（在水相中）的方程。最后，对两相滴定进行了全面描述，包括所有决定“可滴定性”的参数。通过文献实例说明了所发展理论的优点。
