Maini C L, Antonelli Incalzi R, Bonetti M G, Valle G, Montenero A S
Nuklearmedizin. 1985 Aug;24(4):159-63.
The aim of the study was to correlate diastolic function, as evaluated by peak filling rate (PFR) and relative time (TPFR), with the severity of ischemic heart disease, as evaluated by exercise electrocardiography. Accordingly, 83 ischemic patients with effort angina, but normal ejection function at rest and normal left ventricular size, were studied by equilibrium radionuclide angiocardiography within two weeks from the exercise ECG. Diastolic dysfunction, as determined from PFR and, to a lesser extent, from TPFR, is common in patients with ischemic heart disease and normal systolic function. The prevalence and severity of such dysfunction is related more to the severity of the ischemia, as evaluated by the exercise ECG, than to the presence of an old myocardial infarction. Such findings are consistent with the hypothesis that PFR reflects mainly the early diastolic active uncoupling process.
本研究旨在将通过峰值充盈率（PFR）和相对时间（TPFR）评估的舒张功能与通过运动心电图评估的缺血性心脏病严重程度相关联。因此，对83例劳力性心绞痛的缺血患者进行了研究，这些患者静息时射血功能正常且左心室大小正常，在运动心电图检查后的两周内通过平衡放射性核素心血管造影进行研究。由PFR确定的舒张功能障碍，以及在较小程度上由TPFR确定的舒张功能障碍，在收缩功能正常的缺血性心脏病患者中很常见。这种功能障碍的患病率和严重程度与通过运动心电图评估的缺血严重程度的相关性，比与陈旧性心肌梗死的存在相关性更大。这些发现与PFR主要反映舒张早期主动解偶联过程的假设一致。
