Ladino Liliana, Demmelmair Hans, Segura María Teresa, Escudero-Marin Mireia, Grote Veit, Koletzko Berthold, Campoy Cristina
Department Pediatrics, Dr. von Hauner Children's Hospital, Division of Metabolic and Nutritional Medicine, LMU University Hospitals, LMU-Ludwig-Maximilians-Universität München, 80337 Munich, Germany.
German Center for Child and Adolescent Health, 81377 Munich, Germany.
Nutrients. 2025 Jul 22;17(15):2394. doi: 10.3390/nu17152394.
Fatty acid status during the perinatal period is important for optimal offspring growth and development. : We aimed to test the association between maternal fatty acid (FA) intake during the third trimester of pregnancy and the FA composition of placental phospholipids, a marker of maternal fatty acid status. : This cohort study was performed on 54 mothers participating in the PREOBE study. Maternal dietary intake was assessed with prospective 7-day food diaries at 34 weeks of gestation. Placenta samples were collected immediately after delivery and phospholipid FA was quantified with established methods. Data were analyzed with Pearson correlations and linear regression models, with adjustment for confounding factors. : Total energy intake was 2019 ± 527 kcal/d (mean ± SD) and total fat intake of the mothers was 87 ± 35 g/day. Myristic, stearic, oleic, and α-linolenic acid intakes were modestly correlated with placental percentages, with r-values ≤ 0.33. Only docosahexaenoic (DHA) acid intake (%-energy, %-fat, and g/d) showed r-values > 0.4 for the correlation with placenta phospholipids. Intake of other fatty acids, including arachidonic acid, was not associated with the placenta percentage. Linear regression models considering confounders showed only dietary DHA intake significant associations. Total fat intake did not interfere with the association of DHA intake with placental incorporation. : DHA and arachidonic acid are enriched in the placenta, but only placental DHA content seems modifiable by maternal dietary DHA intake.
围产期的脂肪酸状态对后代的最佳生长和发育至关重要。我们旨在测试孕期第三个月母体脂肪酸（FA）摄入量与胎盘磷脂的FA组成之间的关联，胎盘磷脂是母体脂肪酸状态的一个指标。这项队列研究是对54名参与PREOBE研究的母亲进行的。在妊娠34周时，通过前瞻性7天食物日记评估母体饮食摄入量。分娩后立即采集胎盘样本，并用既定方法对磷脂FA进行定量。数据采用Pearson相关性分析和线性回归模型进行分析，并对混杂因素进行调整。总能量摄入量为2019±527千卡/天（平均值±标准差），母亲的总脂肪摄入量为87±35克/天。肉豆蔻酸、硬脂酸、油酸和α-亚麻酸的摄入量与胎盘百分比呈适度相关，r值≤0.33。只有二十二碳六烯酸（DHA）的摄入量（能量百分比、脂肪百分比和克/天）与胎盘磷脂的相关性r值>0.4。其他脂肪酸的摄入量，包括花生四烯酸，与胎盘百分比无关。考虑混杂因素的线性回归模型显示，只有膳食DHA摄入量有显著关联。总脂肪摄入量并未干扰DHA摄入量与胎盘掺入之间的关联。DHA和花生四烯酸在胎盘中含量丰富，但只有胎盘DHA含量似乎可通过母体膳食DHA摄入量进行调节。
