1型糖尿病儿童和青少年的骨骼健康:优化骨质积累与预防骨折

Bone Health in Children and Adolescents with Type 1 Diabetes: Optimizing Bone Accrual and Preventing Fractures.

作者信息

Levran Neriya, Shalev-Goldman Einat, Levy-Shraga Yael

机构信息

Pediatric Endocrinology and Diabetes Unit, The Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Ramat-Gan 5262000, Israel.

The Institute of Biochemistry, Food Science and Nutrition, The Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot 7610001, Israel.

出版信息

Nutrients. 2025 Jul 23;17(15):2400. doi: 10.3390/nu17152400.

Abstract

Children and adolescents with type 1 diabetes (T1D) often experience abnormalities in bone health. Studies have consistently demonstrated that youth with T1D have lower bone mineral density (BMD) compared to their healthy peers. Additionally, children with T1D show impaired bone microarchitecture and reduced bone turnover. These factors collectively contribute to an increased risk of fractures across the life span of this population. To optimize bone accrual and reduce fracture risk, several strategies can be employed during childhood and adolescence. First, maintaining good glycemic control is critical, as poor glycemic control has been associated with lower BMD and an increased risk of fractures. Second, specific nutritional recommendations can help improve bone health, including a balanced diet, adequate calcium and vitamin D intake, and careful monitoring of both macronutrient and micronutrient intake. Third, regular physical activity plays a vital role. A systematic review and meta-analysis have shown that youth with T1D are generally less physically active, more sedentary, and have lower cardiorespiratory fitness levels than their non-diabetic peers. This review emphasizes targeted strategies aimed at optimizing skeletal health in the pediatric population with T1D, with a particular focus on the critical roles of glycemic control, nutritional adequacy, and regular physical activity. These modifiable factors may contribute to the reduction of fracture risk across the life span in individuals with T1D.

摘要

1型糖尿病(T1D)患儿和青少年常常存在骨骼健康异常。研究一直表明,与健康同龄人相比,患有T1D的青少年骨矿物质密度(BMD)较低。此外,T1D患儿的骨微结构受损,骨转换减少。这些因素共同导致该人群在整个生命周期内骨折风险增加。为了优化骨量积累并降低骨折风险,在儿童期和青少年期可采用多种策略。首先,保持良好的血糖控制至关重要,因为血糖控制不佳与较低的BMD以及骨折风险增加有关。其次,特定的营养建议有助于改善骨骼健康,包括均衡饮食、充足的钙和维生素D摄入,以及仔细监测常量营养素和微量营养素的摄入。第三,定期体育活动起着至关重要的作用。一项系统评价和荟萃分析表明,与非糖尿病同龄人相比,患有T1D的青少年总体上身体活动较少、久坐不动,心肺适能水平较低。本综述强调了旨在优化患有T1D的儿科人群骨骼健康的针对性策略,特别关注血糖控制、营养充足和定期体育活动的关键作用。这些可改变的因素可能有助于降低T1D患者在整个生命周期内的骨折风险。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0830/12348532/c6a8110bfe14/nutrients-17-02400-g001.jpg

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