Othman Rym Ben, Sassi Mouna Ben, Hammamia Syrine Ben, Dziri Chadli, Zanina Youssef, Salem Kamel Ben, Jamoussi Henda
Institut National de Nutrition et de Technologie Alimentaire de Tunis, 11 Rue Jbal Lakhdhar, Tunis 1007, Tunisia.
Faculty of Medicine of Tunis, University of Tunis El Manar, 13 Rue Jbal Lakhdhar, Tunis 1007, Tunisia.
Nutrients. 2025 Jul 29;17(15):2467. doi: 10.3390/nu17152467.
Probiotics can modulate the microbiota and decrease uric acid levels.
This meta-analysis aimed to assess the effects of probiotics on uric acid levels.
The keywords "probiotics", "uric acid", "gout", "hyperuricemia" were searched in PubMed Medline, EMBASE, Web of Science, and Google Scholar. The search was limited to the English, French, Italian, and Spanish languages, and to the period between 1 January 2000 to 30 August 2024. We included RCTs and observational studies comparing probiotics to placebo. We excluded studies reporting (1) prebiotics, symbiotics, or postbiotics, (2) animal studies, and (3) case reports, commentaries, or reviews. Two independent reviewers performed quality assessment and data extraction. This meta-analysis was performed according to the PRISMA 2020 and AMSTAR 2 guidelines. The main outcome measure was uric acid levels "after-before" probiotic versus placebo interventions. Forest plots summarized the data using a random model.
Nine studies included 394 patients, of whom 201 were treated with probiotics and 193 with placebo. There was a statistically significant difference in favor of the probiotic group compared with the control group regarding the main outcome measure. However, substantial heterogeneity was noted, explained (after applying subgroup analysis and meta-regression) by the following moderators: continent, diseased/healthy, male sex, and monostrain probiotics.
This meta-analysis demonstrates that probiotics reduced uric acid levels in Asian males who had disease and were treated with monostrain probiotics.
益生菌可调节微生物群并降低尿酸水平。
本荟萃分析旨在评估益生菌对尿酸水平的影响。
在PubMed Medline、EMBASE、科学网和谷歌学术中搜索关键词“益生菌”“尿酸”“痛风”“高尿酸血症”。搜索限于英语、法语、意大利语和西班牙语，时间范围为2000年1月1日至2024年8月30日。我们纳入了比较益生菌与安慰剂的随机对照试验（RCT）和观察性研究。我们排除了报告（1）益生元、合生元或后生元的研究，（2）动物研究，以及（3）病例报告、评论或综述。两名独立的评审员进行质量评估和数据提取。本荟萃分析根据PRISMA 2020和AMSTAR 2指南进行。主要结局指标是益生菌与安慰剂干预后的尿酸水平“前后”对比。森林图使用随机模型汇总数据。
9项研究纳入了394例患者，其中201例接受益生菌治疗，193例接受安慰剂治疗。在主要结局指标方面，与对照组相比，益生菌组有统计学显著差异。然而，观察到存在显著异质性，（在应用亚组分析和Meta回归后）由以下因素解释：大洲、患病/健康、男性以及单一菌株益生菌。
本荟萃分析表明，益生菌可降低患有疾病且接受单一菌株益生菌治疗的亚洲男性的尿酸水平。
