Brownlie B E, Jensen C A, Turner J G, Macbeth W A, Donald R A
Clin Endocrinol (Oxf). 1977 Aug;7(2):159-65. doi: 10.1111/j.1365-2265.1977.tb01308.x.
The pituitary-thyroid axis was assessed 1 month after surgery by thyrotrophin releasing hormone (TRH) testing in thirty thyrotoxic patients treated by subtotal thyroidectomy and eleven patients with toxic uninodular goitre. All toxic nodule patients gave essentially normal TRH responses and have remained clinically and biochemically euthyroid at follow-up. Only seven of the thirty subtotal thyroidectomy patients had normal TRH tests when assessed 1 month post thyroidectomy -sixteen patients showed increased response, six gave flat responses, and one showed an anomalous minimal response. Follow-up TRH tests 12 months postthyroidectomy have shown a tendency for TRH responsiveness to return towards normal, but two patients with flat TRH tests have required radioiodine for relapse and four TRH hyperresponders are currently receiving thyroxine replacement therapy.
在接受甲状腺次全切除术治疗的30例甲状腺毒症患者和11例毒性单结节性甲状腺肿患者术后1个月，通过促甲状腺激素释放激素（TRH）试验评估垂体 - 甲状腺轴。所有毒性结节患者的TRH反应基本正常，在随访中临床和生化指标均保持甲状腺功能正常。在甲状腺次全切除术后1个月进行评估时，30例患者中只有7例TRH试验结果正常，16例反应增强，6例无反应，1例反应异常微弱。甲状腺切除术后12个月的随访TRH试验显示，TRH反应性有恢复正常的趋势，但2例TRH试验无反应的患者因复发需要进行放射性碘治疗，4例TRH反应增强的患者目前正在接受甲状腺素替代治疗。
