Agafonova Aleksandra, Prinzi Chiara, Trovato Salinaro Angela, Ledda Caterina, Cosentino Alessia, Cambria Maria Teresa, Anfuso Carmelina Daniela, Lupo Gabriella
Department of Biomedical and Biotechnological Sciences, Section of Medical Biochemistry, University of Catania, 95123 Catania, Italy.
Department of Biomedical and Biotechnological Sciences, Section of Clinical Biochemistry, University of Catania, 95123 Catania, Italy.
Int J Mol Sci. 2025 Jul 28;26(15):7301. doi: 10.3390/ijms26157301.
Multiple myeloma (MM) is an incurable malignancy characterized by the proliferation of abnormal plasma cells within the bone marrow, followed by potential dissemination to extramedullary sites. The bone marrow barrier (BMB) plays a pivotal role in plasma cell homing and disease progression. Bone marrow endothelial cells (BMECs) and bone marrow stromal cells (BMSCs), through their interactions with MM cells, secrete adhesion molecules, angiogenic cytokines, anti-apoptotic factors, and growth-promoting signals that support MM cell survival and proliferation. This review examines the components of the BMB and the major pathways involved in MM pathogenesis. Targeting the interactions between MM cells and the BMB may offer novel therapeutic opportunities.
多发性骨髓瘤（MM）是一种无法治愈的恶性肿瘤，其特征是骨髓内异常浆细胞增殖，随后可能扩散至髓外部位。骨髓屏障（BMB）在浆细胞归巢和疾病进展中起关键作用。骨髓内皮细胞（BMECs）和骨髓基质细胞（BMSCs）通过与MM细胞相互作用，分泌支持MM细胞存活和增殖的黏附分子、血管生成细胞因子、抗凋亡因子和促生长信号。本文综述了BMB的组成成分以及MM发病机制中涉及的主要途径。针对MM细胞与BMB之间的相互作用可能提供新的治疗机会。
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