Reaction products of dimethyl sulfoxide with 5,5-disubstituted barbituric acids and their biological properties.
作者信息
Czuba W, Kasperek L, Prelicz D, Borkowska B, Bogdal M, Krzywosiński L, Przemyk B
出版信息
Pol J Pharmacol Pharm. 1985 Jul-Aug;37(4):533-40.
PMID:4080647
Abstract
In the reaction of 5,5-disubstituted barbituric acids 1-5 with DMSO mixtures of compounds with one (6, 8, 10, 12) or two methylthiomethyl groups (7, 9, 11, 13) at one or both nitrogen atom are formed. Some of obtained compounds were screened for their central action namely anticonvulsant activity.
摘要
相似文献
1
Reaction products of dimethyl sulfoxide with 5,5-disubstituted barbituric acids and their biological properties.
Pol J Pharmacol Pharm. 1985 Jul-Aug;37(4):533-40.
2
Neuropharmacological screening of newly-synthesized 2-substituted derivatives of the barbituric acid.
Acta Physiol Pharmacol Bulg. 1985;11(3):44-50.
3
Benzothiazole incorporated barbituric acid derivatives: synthesis and anticonvulsant screening.含苯并噻唑的巴比妥酸衍生物：合成与抗惊厥活性筛选
Arch Pharm (Weinheim). 2009 Aug;342(8):462-8. doi: 10.1002/ardp.200900002.
4
Pharmacological and behavioral effects of mono- and disubstituted chlorpromazine derivatives.单取代和双取代氯丙嗪衍生物的药理及行为效应。
Adv Biochem Psychopharmacol. 1974;9(0):617-31.
5
Fluotracen: a tricyclic compound with the combined properties of antidepressants and antipsychotics in animals.
Arzneimittelforschung. 1977;27(8):1589-95.
6
Pharmacology of 7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one (lorazepam; Wy 4036).
Arzneimittelforschung. 1971 Jul;21(7):1049-55.
7
Acyl derivatives of 1,5-benzodiazepines. III. Acyl derivatives of ethyl ester of 4-methyl-1H-tetrahydro-1,5-benzodiazepine-2-carboxylic acid.
Pol J Pharmacol Pharm. 1988 Sep-Oct;40(5):471-80.
8
[Synthesis and the effect of new perhydro-1,4,7-oxadiazonine derivatives on the central nervous system].
Acta Pol Pharm. 1983;40(4):435-44.
9
[Synthesis and pharmacological properties of aminoalkyl esters of nicotinic acid derivatives].
Acta Pol Pharm. 1979;36(6):657-65.
10
Chemical, pharmacological, and metabolic considerations on thiothixene. Introduction: chemical and pharmacological relationship of thioxanthenes and phenothiazines.
Adv Biochem Psychopharmacol. 1974;9(0):471-80.
Zotero 插件