Jaeken Laurent, Manoj Kelath Murali
Department of Industrial Sciences and Technology, Karel de Grote-Hogeschool, Antwerp University Association, Salesianenlaan 90, 2660 Antwerpen, Belgium.
Satyamjayatu: The Science & Ethics Foundation, Shoranur-2, Palakkad 679122, Kerala, India.
Int J Mol Sci. 2025 Aug 5;26(15):7542. doi: 10.3390/ijms26157542.
The paradigm-shift idea of murburn concept is no hypothesis but developed directly from fundamental facts of cellular/ecological existence. Murburn involves spontaneous and stochastic interactions (mediated by murzymes) amongst the molecules and unbound ions of cells. It leads to ffective harge eparation (ECS) and formation/recruitment of iffusible eactive pecies (DRS, like radicals whose reactions enable ATP-synthesis and thermogenesis) and emission of radiations (UV/Vis to ELF). These processes also lead to a hemo-lectromagnetic atrix (CEM), ascertaining that living cell/organism react/function as a coherent unit. Murburn concept propounds the true utility of oxygen: generating DRS (with catalytic and electrical properties) on the way to becoming water, the life solvent, and ultimately also leading to phase-based macroscopic homeostatic outcomes. Such a layout enables cells to become imple hemical ngines (SCEs) with owering, oherence, omeostasis, lectro-echanical and ensing-response (PCHEMS; life's short-term "intelligence") abilities. In the current review, we discuss the coacervate nature of cells and dwell upon the ways and contexts in which various radiations (either incident or endogenously generated) could interact in the new scheme of cellular function. Presenting comparative evidence/arguments and listing of systems with murburn models, we argue that the new perceptions explain life processes better and urge the community to urgently adopt murburn bioenergetics and adapt to its views. Further, we touch upon some distinct scientific and sociological contexts with respect to the outreach of murburn concept. It is envisaged that greater awareness of murburn could enhance the longevity and quality of life and afford better approaches to therapies.
“微燃烧概念”的范式转变理念并非假设,而是直接源于细胞/生态存在的基本事实。微燃烧涉及细胞内分子和游离离子之间由微酶介导的自发随机相互作用。它导致有效电荷分离(ECS)以及可扩散活性物种(DRS,如自由基,其反应可实现ATP合成和产热)的形成/募集和辐射(从紫外线/可见光到极低频)的发射。这些过程还导致形成一个血液电磁矩阵(CEM),确定活细胞/生物体作为一个连贯的单元进行反应/发挥功能。微燃烧概念揭示了氧气的真正效用:在变成生命溶剂水的过程中产生具有催化和电学性质的DRS,最终还导致基于相的宏观稳态结果。这样的布局使细胞能够成为具有发电、相干性、稳态、机电和传感响应(PCHEMS;生命的短期“智能”)能力的简单化学引擎(SCE)。在当前的综述中,我们讨论了细胞的凝聚性质,并详述了各种辐射(无论是入射的还是内源性产生的)在细胞功能新方案中可能相互作用的方式和背景。通过提供比较证据/论据以及列出具有微燃烧模型的系统列表,我们认为新的观点能更好地解释生命过程,并敦促科学界迫切采用微燃烧生物能学并接受其观点。此外,我们还涉及了与微燃烧概念推广相关的一些独特科学和社会学背景。可以设想,对微燃烧有更深入的了解可以提高寿命和生活质量,并提供更好地治疗方法。