Pavalean Mihai Ioan, Dobre Maria, Pelisenco Iulia Andreea, Madan Victor Lucian, Milanesi Elena, Hinescu Mihail Eugen
Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Emergency University Central Military Hospital, 010825 Bucharest, Romania.
Int J Mol Sci. 2025 Aug 5;26(15):7546. doi: 10.3390/ijms26157546.
Bladder cancer (BC) is the most frequent cancer of the urinary system and one of the most common malignancies in the world. In the last decade, many studies have been conducted to better understand the pathophysiological mechanisms of BC to find innovative markers for disease monitoring and treatment. In this study, we aim to identify miRNAs whose expression is associated with specific tumoral characteristics and risks of disease progression. Forty-one BC patients were enrolled in this study. The expression of 84 miRNAs was evaluated by qRT-PCR analysis on tumoral and peritumoral tissues. The results highlighted the association of the miRNA-17-92 cluster with BC, with miR-17-5p, miR-18a-5p, miR-19a-3p, and miR-20a-5p (members of this cluster) being upregulated in the tumoral tissue and correlated with muscle invasion and tumor grading. Taken together, our study identified a panel of 26 dysregulated miRNAs in BC, some of which may be associated with aggressiveness and the risk of progression of this malignancy.
膀胱癌（BC）是泌尿系统最常见的癌症，也是全球最常见的恶性肿瘤之一。在过去十年中，人们进行了许多研究，以更好地了解膀胱癌的病理生理机制，寻找用于疾病监测和治疗的创新标志物。在本研究中，我们旨在鉴定其表达与特定肿瘤特征和疾病进展风险相关的微小RNA（miRNA）。本研究纳入了41例膀胱癌患者。通过对肿瘤组织和瘤旁组织进行定量逆转录聚合酶链反应（qRT-PCR）分析，评估了84种miRNA的表达。结果突出显示了miRNA-17-92簇与膀胱癌的关联，该簇成员miR-17-5p、miR-18a-5p、miR-19a-3p和miR-20a-5p在肿瘤组织中上调，并与肌肉浸润和肿瘤分级相关。综上所述，我们的研究鉴定出了一组在膀胱癌中失调的26种miRNA，其中一些可能与这种恶性肿瘤的侵袭性和进展风险相关。
