Lou Li, Li Jianhua, Chen Weiqiang, Zhu Cassie Shu, Qiang Xiaoling, Wang Haichao
The Feinstein Institutes for Medical Research, Northwell Health, 350 Community Drive, Manhasset, NY 11030, USA.
Department of Emergency Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, 500 Hofstra Blvd., Hempstead, NY 11549, USA.
Int J Mol Sci. 2025 Aug 7;26(15):7643. doi: 10.3390/ijms26157643.
Human dermcidin (DCD) is synthesized as a 110-amino acid precursor (pre-dermcidin, pre-DCD) containing a 19-residue leader signal sequence, which is removed to produce a leader-less pro-domain-containing peptide termed as pro-dermcidin, pro-DCD. Pro-DCD can be secreted by human eccrine sweat glands and then cleaved into antimicrobial peptides, such as dermcidin (DCD). Emerging evidence suggests that pro-DCD has broader physiological roles beyond antimicrobial defense, potentially serving as a therapeutic agent for inflammatory diseases like sepsis. In this review, we summarize recent evidence supporting pro-DCD as a regulator of innate immunity in sepsis.
人皮肤杀菌肽（DCD）最初被合成为一种含110个氨基酸的前体（前皮肤杀菌肽，pre-DCD），其包含一个19个残基的前导信号序列，该序列被去除后产生一种不含前导序列但含前结构域的肽，称为前皮肤杀菌肽原，pro-DCD。Pro-DCD可由人外分泌汗腺分泌，然后裂解为抗菌肽，如皮肤杀菌肽（DCD）。新出现的证据表明，pro-DCD除了具有抗菌防御作用外，还具有更广泛的生理作用，可能作为脓毒症等炎症性疾病的治疗剂。在本综述中，我们总结了最近支持pro-DCD作为脓毒症中固有免疫调节因子的证据。
