Poenaru Daniela, Sandulescu Miruna Ioana, Furculescu Catalin, Potcovaru Claudia Gabriela
Rehabilitation Department, Carol Davila University of Medicine, 050474 Bucharest, Romania.
National Institute of Rehabilitation, 030167 Bucharest, Romania.
J Clin Med. 2025 Jul 24;14(15):5252. doi: 10.3390/jcm14155252.
The objective of this review is to document the modalities to enhance the neuromuscular effects of botulinum toxin (BoNT) injection in spastic patients with multiple sclerosis (MS). We conducted a literature review focusing on studies involving BoNT administration for MS-related spasticity and the use of adjunctive therapies aimed at reducing dosage and increasing injection intervals. The findings revealed a limited number of studies specific to MS patients, addressing only a few adjunct techniques, including electrical stimulation, vibration therapy, physical exercise, and extracorporeal shock wave therapy. These preliminary findings highlight the need for further research into integrative therapeutic strategies tailored specifically to the MS population.
本综述的目的是记录增强肉毒杆菌毒素（BoNT）注射对多发性硬化症（MS）痉挛患者神经肌肉作用的方法。我们进行了一项文献综述，重点关注涉及BoNT治疗MS相关痉挛的研究，以及旨在减少剂量和延长注射间隔的辅助治疗方法的使用。研究结果显示，针对MS患者的特定研究数量有限，仅涉及少数辅助技术，包括电刺激、振动疗法、体育锻炼和体外冲击波疗法。这些初步研究结果凸显了针对MS人群进一步研究综合治疗策略的必要性。
