Kwak Ji Yoon, Jeon Hankyu, Kwon Hyeon Uk, Kim Jae Eun, Kim Seong Je, Han Ji Hee, Cha Ra Ri, Lee Jae Min, Lee Sang Soo
Department of Internal Medicine, Gyeongsang National University Changwon Hospital, Gyeongsang National University School of Medicine, Changwon 51472, Republic of Korea.
Institute of Health Sciences, Gyeongsang National University, Jinju 52727, Republic of Korea.
J Clin Med. 2025 Jul 26;14(15):5286. doi: 10.3390/jcm14155286.
: Hypoxic hepatitis contributes to the development and progression of multiple organ failure (MOF). We evaluated whether MOF is associated with 30-day mortality in patients with hypoxic hepatitis. : This retrospective study included 1011 patients diagnosed with hypoxic hepatitis at two centers in South Korea between 2010 and 2021. Organ failure was defined as a sequential organ failure assessment score ≥ 3 for each individual organ system. : Circulatory failure was the most common organ failure (n = 521), followed by respiratory (n = 380), cerebral (n = 307), renal (n = 236), coagulation (n = 182), and hepatic failure (n = 73). The proportions of patients without organ failure, with single organ failure, and with MOF were 28.7%, 22.3%, and 49.1%, respectively, with corresponding 30-day mortality rates of 17.9%, 29.3%, and 70.0%. In the multivariate Cox regression model, the presence of MOF grade 1 (two organ failures), grade 2 (three organ failures), and grade 3 (≥four organ failures) increased the risk of 30-day mortality by approximately threefold, fourfold, and fivefold, respectively, compared to patients without MOF. : MOF is frequently observed in patients with hypoxic hepatitis and is a strong independent predictor of short-term mortality.
缺氧性肝炎会促使多器官功能衰竭（MOF）的发生和发展。我们评估了MOF是否与缺氧性肝炎患者的30天死亡率相关。
这项回顾性研究纳入了2010年至2021年期间在韩国两个中心诊断为缺氧性肝炎的1011例患者。器官功能衰竭定义为每个单独器官系统的序贯器官衰竭评估评分≥3。
循环衰竭是最常见的器官功能衰竭（n = 521），其次是呼吸衰竭（n = 380）、脑衰竭（n = 307）、肾衰竭（n = 236）、凝血功能衰竭（n = 182）和肝衰竭（n = 73）。无器官功能衰竭、单器官功能衰竭和MOF患者的比例分别为28.7%、22.3%和49.1%，相应的30天死亡率分别为17.9%、29.3%和70.0%。在多变量Cox回归模型中，与无MOF的患者相比，1级MOF（两个器官功能衰竭）、2级MOF（三个器官功能衰竭）和3级MOF（≥四个器官功能衰竭）患者的30天死亡风险分别增加约三倍、四倍和五倍。
MOF在缺氧性肝炎患者中经常出现，并且是短期死亡率的强有力独立预测因素。
