Cirillo Bruno, Duranti Giulia, Cirocchi Roberto, Comotti Francesca, Zambon Martina, Sapienza Paolo, Matteucci Matteo, Mingoli Andrea, Giovampietro Sara, Brachini Gioia
Department of Surgery, Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, Italy.
Department of Surgery, General Surgery, University of Perugia, 06129 Perugia, Italy.
J Clin Med. 2025 Jul 26;14(15):5288. doi: 10.3390/jcm14155288.
Renal trauma accounts for approximately 3-5% of all trauma cases, predominantly affecting young males. The most common etiology is blunt trauma, particularly due to road traffic accidents, and it frequently occurs as part of polytrauma involving multiple organ systems. Management strategies are primarily dictated by hemodynamic stability, overall clinical condition, comorbidities, and injury severity graded according to the AAST classification. This study aimed to evaluate the effectiveness of non-operative management (NOM) in high-grade renal trauma (AAST grades III-V), beyond its established role in low-grade injuries (grades I-II). Secondary endpoints included the identification of independent prognostic factors for NOM failure and in-hospital mortality. We conducted a retrospective observational study including patients diagnosed with blunt renal trauma who presented to the Emergency Department of Policlinico Umberto I in Rome between 1 January 2013 and 30 April 2024. Collected data comprised demographics, trauma mechanism, vital signs, hemodynamic status (shock index), laboratory tests, blood gas analysis, hematuria, number of transfused RBC units in the first 24 h, AAST renal injury grade, ISS, associated injuries, treatment approach, hospital length of stay, and mortality. Statistical analyses, including multivariable logistic regression, were performed using SPSS v28.0. A total of 244 patients were included. Low-grade injuries (AAST I-II) accounted for 43% (n = 105), while high-grade injuries (AAST III-V) represented 57% (n = 139). All patients with low-grade injuries were managed non-operatively. Among high-grade injuries, 124 patients (89%) were treated with NOM, including observation, angiography ± angioembolization, stenting, or nephrostomy. Only 15 patients (11%) required nephrectomy, primarily due to persistent hemodynamic instability. The overall mortality rate was 13.5% (33 patients) and was more closely associated with the overall injury burden than with renal injury severity. Multivariable analysis identified shock index and active bleeding on CT as independent predictors of NOM failure, whereas ISS and age were significant predictors of in-hospital mortality. Notably, AAST grade did not independently predict either outcome. In line with the current international literature, our study confirms that NOM is the treatment of choice not only for low-grade renal injuries but also for carefully selected hemodynamically stable patients with high-grade trauma. Our findings highlight the critical role of physiological parameters and overall ISS in guiding management decisions and underscore the need for individualized assessment to minimize unnecessary nephrectomies and optimize patient outcomes.
肾外伤约占所有外伤病例的3%-5%,主要影响年轻男性。最常见的病因是钝性外伤,尤其是道路交通事故所致,且常作为涉及多个器官系统的多发伤的一部分出现。治疗策略主要取决于血流动力学稳定性、整体临床状况、合并症以及根据美国创伤外科学会(AAST)分类法分级的损伤严重程度。本研究旨在评估非手术治疗(NOM)在高级别肾外伤(AAST III-V级)中的有效性,而非其在低级别损伤(I-II级)中已确立的作用。次要终点包括确定NOM失败和院内死亡的独立预后因素。我们进行了一项回顾性观察研究,纳入了2013年1月1日至2024年4月30日期间在罗马翁贝托一世综合医院急诊科就诊、被诊断为钝性肾外伤的患者。收集的数据包括人口统计学信息、外伤机制、生命体征、血流动力学状态(休克指数)、实验室检查、血气分析、血尿、最初24小时内输注红细胞单位数量、AAST肾损伤分级、损伤严重度评分(ISS)、相关损伤、治疗方法、住院时间和死亡率。使用SPSS v28.0进行包括多变量逻辑回归在内的统计分析。共纳入244例患者。低级别损伤(AAST I-II级)占43%(n = 105),而高级别损伤(AAST III-V级)占57%(n = 139)。所有低级别损伤患者均采用非手术治疗。在高级别损伤患者中,124例(89%)接受了NOM治疗,包括观察、血管造影±血管栓塞、支架置入或肾造瘘术。仅15例(11%)患者需要进行肾切除术,主要原因是血流动力学持续不稳定。总体死亡率为13.5%(33例患者),与整体损伤负担的相关性比与肾损伤严重程度的相关性更强。多变量分析确定休克指数和CT上的活动性出血是NOM失败的独立预测因素,而ISS和年龄是院内死亡的显著预测因素。值得注意的是,AAST分级并不能独立预测任何一种结果。与当前国际文献一致,我们的研究证实,NOM不仅是低级别肾损伤的首选治疗方法,也是经过精心挑选的血流动力学稳定的高级别外伤患者的首选治疗方法。我们的研究结果突出了生理参数和整体ISS在指导治疗决策中的关键作用,并强调了进行个体化评估以尽量减少不必要的肾切除术并优化患者预后的必要性。