Molasy Bartosz, Frydrych Mateusz, Kuchciński Rafał, Głuszek Stanisław
Medical College, The Jan Kochanowski University, 25-317 Kielce, Poland.
Department of General Surgery, St. Alexander Hospital, 25-316 Kielce, Poland.
J Clin Med. 2025 Aug 7;14(15):5564. doi: 10.3390/jcm14155564.
Chronic wounds are a growing clinical challenge due to their prolonged healing time and associated healthcare burden. Combined therapeutic approaches, including topical oxygen therapy (TOT) and negative-pressure wound therapy (NPWT), have shown promise in enhancing wound healing. This pilot exploratory study aimed to assess the clinical effectiveness of combined TOT and NPWT in chronic wound treatment and to explore the prognostic value of selected laboratory and thermographic markers. Eighteen patients with chronic wounds due to type 2 diabetes mellitus or chronic venous insufficiency were treated with either TOT alone (control group) or TOT combined with NPWT (intervention group). Wound characteristics, thermographic data, and laboratory parameters (NLR, MLR, PLR, CRP, and total protein) were collected at baseline and during therapy. The primary endpoints were the total treatment duration and complete wound closure. Statistical analyses were exploratory and used non-parametric tests, correlation analyses, and simple linear regression. Ulcer duration was significantly associated with the wound surface area. Lower serum total protein levels correlated negatively with ulcer duration, wound size, and granulation tissue area. A significant reduction in treatment duration was observed in the intervention group compared to the controls. One strong correlation was found between MLR and peripheral wound temperature on day 7 in the control group. No significant group differences were observed in wound size or thermographic measures after one week of treatment. Combining TOT and NPWT may reduce treatment duration in chronic wound management. Selected laboratory and thermographic markers show promise as prognostic tools. These exploratory findings require confirmation in larger, randomized trials.
由于愈合时间延长以及相关的医疗负担，慢性伤口已成为日益严峻的临床挑战。包括局部氧疗（TOT）和负压伤口治疗（NPWT）在内的联合治疗方法已显示出促进伤口愈合的前景。这项初步探索性研究旨在评估TOT和NPWT联合治疗慢性伤口的临床效果，并探索选定的实验室和热成像标记物的预后价值。18例因2型糖尿病或慢性静脉功能不全导致慢性伤口的患者，分别接受单纯TOT治疗（对照组）或TOT联合NPWT治疗（干预组）。在基线和治疗期间收集伤口特征、热成像数据和实验室参数（中性粒细胞与淋巴细胞比值、单核细胞与淋巴细胞比值、血小板与淋巴细胞比值、C反应蛋白和总蛋白）。主要终点为总治疗持续时间和伤口完全闭合。统计分析为探索性分析，采用非参数检验、相关性分析和简单线性回归。溃疡持续时间与伤口表面积显著相关。血清总蛋白水平较低与溃疡持续时间、伤口大小和肉芽组织面积呈负相关。与对照组相比，干预组的治疗持续时间显著缩短。在对照组中，第7天单核细胞与淋巴细胞比值与外周伤口温度之间存在显著相关性。治疗一周后，两组在伤口大小或热成像测量方面未观察到显著差异。TOT和NPWT联合使用可能会缩短慢性伤口管理的治疗持续时间。选定的实验室和热成像标记物有望作为预后工具。这些探索性结果需要在更大规模的随机试验中得到证实。
