Basu S
Prog Clin Biol Res. 1985;196:265-88.
Evidence has been presented to prove that cathodoluminescence (CL) studies of chromosomes and spread, Giemsa stained chromatin may lead to early detection of structural changes, such as the superstructure of heterochromatin. Several compounds including the potent hallucinogenic drugs, LSD and cocaine, have been discovered to be cathodoluminescent. The main issue confronting the CL applications using biological stains is the need for a clear identification of the source (dye or drug) of CL contrast. Unequivocal proof to this matter has been given by studies in which the time-dependent incorporation of LSD into the non-cathodoluminescent, virtually impermeable human hairs have been presented. The major implication of this finding is in forensic applications.
已有证据证明，对染色体以及展开的吉姆萨染色染色质进行阴极发光（CL）研究可能会有助于早期发现结构变化，例如异染色质的超结构。已发现包括强效致幻药物麦角酸二乙酰胺（LSD）和可卡因在内的几种化合物具有阴极发光特性。使用生物染色剂进行CL应用面临的主要问题是需要明确识别CL对比度的来源（染料或药物）。关于这一问题的确凿证据来自于相关研究，这些研究展示了LSD随时间掺入到不具有阴极发光特性、几乎不可渗透的人类毛发中的情况。这一发现的主要意义在于法医应用方面。
