Hijazi Ahmed K, El-Khateeb Mohammad, Taha Ziyad A, Alomari Mohammed I, Khwaileh Noor M, Alakhras Abbas I, Al-Momani Waleed M, Elrashidi Ali, Barham Ahmad S
Department of Chemistry, College of Arts and Sciences, University of Petra, P.O. Box 961343, Amman 11196, Jordan.
Department of Chemical Sciences, Faculty of Science and Arts, Jordan University of Science and Technology, P.O. Box 3030, Irbid 22110, Jordan.
Molecules. 2025 Jul 25;30(15):3121. doi: 10.3390/molecules30153121.
Transition metal complexes incorporating fluorinated counter anions represent a significant class of compounds with broad applications in industry, pharmaceuticals, and biomedicine. These fluorinated anions are known to enhance the solubility, stability, and reactivity of the complexes, thereby expanding their functional utility in various chemical and biological contexts.
A set of metal(II) complexes of the general formula [MPy][B(CF)] where (Py = pyridine, M = Mn (), Fe (), Co (), Ni (), Cu (), Zn ()) have been synthesized by direct reaction of metal halides and pyridine in the presence of Ag[B(CF)]. The complexes were characterized using different techniques to assure their purity, such as elemental analysis (EA), electron paramagnetic resonance (EPR) spectroscopy, thermogravimetric analysis (TGA), ultraviolet-visible (UV-Vis) spectroscopy, B-NMR, H-NMR, and FT-IR spectroscopy. The antimicrobial and antifungal properties against different types of bacteria and fungi were studied for all prepared complexes.
The synthesized complexes exhibited broad-spectrum antimicrobial activity, demonstrating variable efficacy compared to the reference antibiotic, oxytetracycline (positive control). Notably, complex displayed exceptional antibacterial activity against , with a minimum inhibitory concentration (MIC) of 4 µg/mL, outperforming the control (MIC = 8 µg/mL). Complexes , , and showed promising activity against , , and , each with MIC values of 8 µg/mL. Conversely, the lowest activity (MIC = 512 µg/mL) was observed for complexes , , and against , , and , respectively. Regarding antifungal properties, complexes and demonstrated the highest activity against , with MIC values of 8 µg/mL, equivalent to that of the positive control, fluconazole. Density functional theory (DFT) calculations confirmed an overall octahedral coordination geometry for all complexes, with tetragonal distortions identified in complexes , , and .
含有氟化抗衡阴离子的过渡金属配合物是一类重要的化合物，在工业、制药和生物医学领域有着广泛的应用。已知这些氟化阴离子可提高配合物的溶解度、稳定性和反应活性，从而扩大其在各种化学和生物学环境中的功能用途。
通过金属卤化物与吡啶在Ag[B(CF)]存在下直接反应，合成了通式为[MPy][B(CF)]的一组金属（II）配合物（其中Py =吡啶，M = Mn（）、Fe（）、Co（）、Ni（）、Cu（）、Zn（））。使用不同技术对配合物进行表征以确保其纯度，如元素分析（EA）、电子顺磁共振（EPR）光谱、热重分析（TGA）、紫外可见（UV-Vis）光谱、B-NMR、H-NMR和傅里叶变换红外（FT-IR）光谱。对所有制备的配合物针对不同类型细菌和真菌的抗菌和抗真菌性能进行了研究。
合成的配合物表现出广谱抗菌活性，与参考抗生素土霉素（阳性对照）相比，显示出不同的功效。值得注意的是，配合物对表现出优异的抗菌活性，最低抑菌浓度（MIC）为4μg/mL，优于对照（MIC = 8μg/mL）。配合物、和对、和表现出有前景的活性，MIC值均为8μg/mL。相反，配合物、和对、和的活性最低（MIC = 512μg/mL）。关于抗真菌性能，配合物和对表现出最高活性，MIC值为8μg/mL，与阳性对照氟康唑相当。密度泛函理论（DFT）计算证实所有配合物的整体八面体配位几何结构，在配合物、和中发现有四方畸变。
