Križman Mitja, Zekič Jure, Šket Primož, Anžlovar Alojz, Zupančič Barbara, Grdadolnik Jože
National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana, Slovenia.
Faculty of Maritime Studies and Transport, University of Ljubljana, Pot pomorščakov 4, 6320 Portorož, Slovenia.
Molecules. 2025 Jul 29;30(15):3179. doi: 10.3390/molecules30153179.
In this study, a new, patented form of a water-soluble cannabidiol (CBD) complex was synthesised and tested. The formation of the complex is based on the interactions, presumably through hydrogen bonding, between cannabidiol and glucosamine, the latter contributing significantly to the increased hydrophilicity. The complex was characterised by chromatography, thermal analysis, nuclear magnetic resonance, Fourier transform infrared spectroscopy, and permeability tests. This complex has a substantially higher water solubility than normal CBD. Permeability tests indicate that it has almost five times lower permeability through lipophilic membranes and less than half the membrane mass retention of conventional CBD. At the same time, its equilibrium concentration is almost four times higher than that of normal CBD. These results suggest that this new form of CBD is a promising candidate for future biological and clinical studies, as it offers improved bioavailability and biodistribution.
在本研究中，合成并测试了一种新型的、获得专利的水溶性大麻二酚（CBD）复合物。该复合物的形成基于大麻二酚与葡萄糖胺之间可能通过氢键形成的相互作用，后者对增加亲水性有显著贡献。通过色谱法、热分析、核磁共振、傅里叶变换红外光谱和渗透性测试对该复合物进行了表征。这种复合物的水溶性比普通CBD高得多。渗透性测试表明，它通过亲脂性膜的渗透性几乎低五倍，并且膜质量保留率不到传统CBD的一半。同时，其平衡浓度几乎是普通CBD的四倍。这些结果表明，这种新型CBD是未来生物学和临床研究的有希望的候选物，因为它具有改善的生物利用度和生物分布。
