Franke G, Schneider T, Siegmund W, Scherber A
Pharmazie. 1985 Aug;40(8):562-3.
Absolute and relative bioavailability of two commercial calcium dobesilate tablets were evaluated in ten healthy volunteers in a cross-over trial using a newly developed HPLC detection method. Both tablet forms were absorbed completely but very slowly thus leading to a flip-flop kinetics. It could be shown that AUC values derived from flip-flop models were comparable with those of normal i. v. kinetics.
采用新开发的高效液相色谱检测方法，在一项交叉试验中对10名健康志愿者评估了两种市售羟苯磺酸钙片剂的绝对生物利用度和相对生物利用度。两种片剂形式均被完全吸收，但吸收非常缓慢，因此导致了反相动力学。结果表明，由反相模型得出的AUC值与正常静脉注射动力学的AUC值相当。
