Xu Tuo, Wu Yongkang, Zheng Changwei, Chen Weijie, Zhang Zhi
Department of Vascular and Thyroid Surgery, The Affiliated Hospital of Guangdong Medical University, Zhanjiang City, Guangdong, P.R. China.
Clin Exp Hypertens. 2025 Dec;47(1):2539180. doi: 10.1080/10641963.2025.2539180. Epub 2025 Aug 13.
Based on Mendelian randomization (MR) methods, this study aims to explore causal associations of uric acid (UA) levels with aortic aneurysms (AAs).
In this MR study, data on UA levels and gout were extracted from genome-wide association study (GWAS) meta-analysis conducted by UK Biobank (UKB) for European population and the Biobank Japan Project (BBJ) for Asian population. Summary statistics of AAs were obtained from different databases. Inverse variance weighted (IVW), weighted-mode, weighted median, MR-Egger, and MR-PRESSO methods were used to examine the potential causal association of UA with AAs.
The IVW estimates indicated that elevated UA level was associated with higher AAA risk among the European population (OR = 1.315, 95%CI: 1.024-1.689). In the Asian population, the UA level was positively linked to the odds of AA (OR = 1.393, 95%CI: 1.061-1.829). In addition, sensitivity analyses through MR leave-one-out and single SNP effect methods showed that these results were relatively robust.
UA may be a potential risk factor for AAs, indicating that clinicians should focus on serum UA levels among populations with high-risk of AAs. Studies to reveal the true relationship between them and clarify the underlying mechanism are still needed in the future.
基于孟德尔随机化（MR）方法，本研究旨在探讨尿酸（UA）水平与主动脉瘤（AA）之间的因果关联。
在这项MR研究中，从英国生物银行（UKB）针对欧洲人群开展的全基因组关联研究（GWAS）荟萃分析以及日本生物银行项目（BBJ）针对亚洲人群的研究中提取了UA水平和痛风的数据。从不同数据库获取了AA的汇总统计数据。采用逆方差加权（IVW）、加权模式、加权中位数、MR-Egger和MR-PRESSO方法来检验UA与AA之间的潜在因果关联。
IVW估计表明，在欧洲人群中，UA水平升高与AAA风险增加相关（OR = 1.315，95%CI：1.024 - 1.689）。在亚洲人群中，UA水平与AA的几率呈正相关（OR = 1.393，95%CI：1.061 - 1.829）。此外，通过MR留一法和单核苷酸多态性效应方法进行的敏感性分析表明，这些结果相对稳健。
UA可能是AA的一个潜在风险因素，这表明临床医生应关注AA高危人群的血清UA水平。未来仍需要开展研究以揭示它们之间的真实关系并阐明潜在机制。
