Del Cerro S, Borrell J
Physiol Behav. 1985 Nov;35(5):667-71. doi: 10.1016/0031-9384(85)90394-4.
The effects of immediate posttraining subcutaneous administration of naloxone (0.25, 1 or 5 mg/kg) on retention behaviour of rats trained in an inhibitory avoidance task, subjected or not to familiarization with the training situation prior to the training trial (pretraining) have been investigated. Naloxone did not influence performance of pretrained rats not subjected to footshock at training. The drug did not significantly modify retention latencies of pretrained rats subjected to a weak footshock. However, administration of naloxone facilitated retention behaviour of non-pretrained rats subjected to a weak footshock. Likewise, naloxone significantly increases retention latencies of pretrained rats subjected to a high footshock at the training trial. These data indicate that naloxone influences retention behaviour depending on the degree of novelty linked to the training situation: a facilitatory effect of the drug is observed when the training trial becomes associated with a clear novel situation for the animals (high footshock in pretrained rats or a weak footshock in non-pretrained animals).
研究了训练后立即皮下注射纳洛酮（0.25、1或5毫克/千克）对在抑制性回避任务中训练的大鼠记忆行为的影响，这些大鼠在训练试验（预训练）之前是否对训练环境进行了熟悉。纳洛酮对在训练时未遭受足部电击的预训练大鼠的表现没有影响。该药物对遭受弱足部电击的预训练大鼠的记忆潜伏期没有显著改变。然而，注射纳洛酮促进了遭受弱足部电击的未预训练大鼠的记忆行为。同样，纳洛酮显著增加了在训练试验中遭受高足部电击的预训练大鼠的记忆潜伏期。这些数据表明，纳洛酮对记忆行为的影响取决于与训练环境相关的新奇程度：当训练试验与动物明显的新奇环境相关联时（预训练大鼠中的高足部电击或未预训练动物中的弱足部电击），可观察到该药物的促进作用。
