Baumert Brittney O, Costello Elizabeth, Li Zhenjiang, Ryder Justin R, Inge Thomas, Jenkins Todd, Sisley Stephanie, Xanthakos Stavra A, Walker Douglas I, Stratakis Nikos, Valvi Damaskini, Bartell Scott M, Slitt Angela L, Kohli Rohit, Rock Sarah, La Merrill Michele A, Eckel Sandrah P, Aung Max T, McConnell Rob, Conti David V, Chatzi Lida
Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Obesity (Silver Spring). 2025 Aug 14. doi: 10.1002/oby.70009.
Weight regain following bariatric surgery remains a clinical challenge, with limited understanding of contributing environmental factors. Per- and polyfluoroalkyl substances (PFAS), persistent chemicals linked to metabolic dysfunction, may influence long-term weight trajectories. This study aimed to evaluate associations between PFAS exposure and changes in BMI, percent weight loss, and waist circumference among adolescents after bariatric surgery.
We included 186 adolescents (mean age: 17.1 years; 76.3% female; 72.0% White) from the Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) cohort who underwent surgery between 2007 and 2012. Anthropometric measurements were collected at baseline and 6, 12, 36, and 60 months post surgery. Presurgical plasma concentrations of seven PFAS were measured using liquid chromatography-tandem mass spectrometry. Associations were estimated using linear mixed-effects models and quantile g-computation.
Higher concentrations of PFOS, PFHxS, and PFHpS were associated with greater BMI regain, reduced percent weight loss, and increased waist circumference from 1 to 5 years post surgery. At PFOS concentrations of 1.45 to 2.94 log ng/mL, annual BMI regain increased from 1.34 to 1.84 kg/m (p = 0.0497). Mixture analyses confirmed cumulative PFAS effects, with sulfonic acids showing the strongest associations.
PFAS exposure was associated with weight regain after bariatric surgery in adolescents, potentially undermining long-term metabolic benefits.
ClinicalTrials.gov identifier NCT00474318.
减肥手术后体重反弹仍是一项临床挑战，目前对相关环境因素的了解有限。全氟和多氟烷基物质（PFAS）是与代谢功能障碍有关的持久性化学物质，可能会影响长期体重变化轨迹。本研究旨在评估青少年减肥手术后PFAS暴露与体重指数（BMI）变化、体重减轻百分比和腰围之间的关联。
我们纳入了青少年减肥手术纵向评估（Teen-LABS）队列中的186名青少年（平均年龄：17.1岁；76.3%为女性；72.0%为白人），他们在2007年至2012年期间接受了手术。在基线以及术后6、12、36和60个月收集人体测量数据。使用液相色谱-串联质谱法测量术前血浆中七种PFAS的浓度。使用线性混合效应模型和分位数g计算来估计关联。
术后1至5年，全氟辛烷磺酸（PFOS）、全氟己烷磺酸（PFHxS）和全氟庚烷磺酸（PFHpS）浓度较高与BMI反弹更大、体重减轻百分比降低以及腰围增加有关。当PFOS浓度为1.45至2.94 log ng/mL时，每年的BMI反弹从1.34 kg/m增加到1.84 kg/m（p = 0.0497）。混合分析证实了PFAS的累积效应，其中磺酸显示出最强的关联。
青少年减肥手术后，PFAS暴露与体重反弹有关，可能会削弱长期的代谢益处。
ClinicalTrials.gov标识符NCT00474318。
Zotero 插件
