Wager Jessica L, Thompson Jennifer A
Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Libin Cardiovascular Institute, Calgary, Alberta, Canada.
Pediatr Res. 2025 May;97(6):1833-1839. doi: 10.1038/s41390-024-03547-z. Epub 2024 Sep 14.
Chemical pollution is one of today's most significant threats to the developmental potential of children worldwide. Maternal exposure to toxicants can perturb sensitive windows of fetal development, indirectly through promoting antenatal disorders, abnormal placental adaptation, or directly through maternal-fetal transport. Current evidence clearly shows that persistent organic chemicals promote hypertensive disorders of pregnancy, placental abnormalities, and fetal growth restriction, whereas findings are less consistent for phthalates and bisphenols. Prospective birth cohorts strongly support a link between adverse neurodevelopmental outcomes and prenatal exposure to flame retardants and organophosphate pesticides. Emerging evidence reveals a potential association between in utero exposure to bisphenols and childhood behavioral disorders, while childhood metabolic health is more consistently associated with postnatal exposure to phthalates and bisphenols. IMPACT: Synthesizes emerging evidence linking modern forms of chemical pollution to antenatal disorders, fetal growth restriction and childhood disorders. Highlights potential developmental impacts of emerging pollutants of concern now ubiquitous in our environment but without regulatory restrictions.
化学污染是当今全球儿童发育潜能面临的最重大威胁之一。母亲接触有毒物质会干扰胎儿发育的敏感窗口期，这既可以通过引发产前疾病、胎盘异常适应间接导致，也可以通过母婴转运直接造成。目前的证据清楚地表明，持久性有机化学物质会引发妊娠高血压疾病、胎盘异常和胎儿生长受限，而邻苯二甲酸盐和双酚的相关研究结果则不太一致。前瞻性出生队列研究有力地支持了不良神经发育结局与产前接触阻燃剂和有机磷农药之间的联系。新出现的证据揭示了子宫内接触双酚与儿童行为障碍之间的潜在关联，而儿童代谢健康则更一致地与出生后接触邻苯二甲酸盐和双酚有关。影响：综合了将现代化学污染形式与产前疾病、胎儿生长受限和儿童疾病联系起来的新出现的证据。强调了我们环境中目前普遍存在但无监管限制的新型污染物对发育的潜在影响。
