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狨猴屏状核的静息态功能连接

Resting-state functional connectivity of the marmoset claustrum.

作者信息

Holzscherer Erin J, Zanini Alessandro, Liu Chun Yin, Everling Stefan, Seminowicz David A

机构信息

Department of Medical Biophysics, Schulich School of Medicine & Dentistry, University of Western Ontario, London, ON, Canada.

Department of Physiology and Pharmacology, Schulich School of Medicine & Dentistry, University of Western Ontario, London, ON, Canada.

出版信息

Imaging Neurosci (Camb). 2025 Aug 12;3. doi: 10.1162/IMAG.a.109. eCollection 2025.

Abstract

The common marmoset () has been recently developed as a nonhuman primate model useful for studying behaviour, neurology, and higher-level cognitive processes considering their phylogenetic proximity to humans. Here, we investigated the resting-state functional connectivity (RSFC) of the marmoset claustrum, a small, highly connected subcortical structure. Using an open resource of 234 functional MRI scans from awake marmosets, we found claustrum connectivity to the prefrontal cortex, posterior parietal cortex, temporal cortices, cingulate cortex, sensory cortices, limbic areas, basal ganglia, and cerebellum. We also found strong functional connectivity to regions and hubs involved in marmoset resting-state networks. These findings demonstrate marmoset claustrum RSFC similar to previous human and non-human primate studies and validate the integration of marmosets into claustrum research.

摘要

普通狨猴()最近已被开发成为一种非人类灵长类动物模型,鉴于其与人类在系统发育上的相近性,该模型对于研究行为、神经学和高级认知过程很有用。在此,我们研究了狨猴屏状核的静息态功能连接(RSFC),屏状核是一个小的、高度连接的皮质下结构。利用来自清醒狨猴的234份功能磁共振成像扫描的开放资源,我们发现屏状核与前额叶皮质、顶叶后皮质、颞叶皮质、扣带回皮质、感觉皮质、边缘区域、基底神经节和小脑存在连接。我们还发现与参与狨猴静息态网络的区域和枢纽存在很强的功能连接。这些发现表明狨猴屏状核的RSFC与之前人类和非人类灵长类动物的研究相似,并验证了将狨猴纳入屏状核研究的合理性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfd4/12344515/9aa48e69263a/IMAG.a.109_fig1.jpg

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