Department of Medical Biophysics, University of Western Ontario, London, Ontario N6A 5C1, Canada.
Centre for Functional and Metabolic Mapping, Robarts Research Institute, University of Western Ontario, London, Ontario N6A 5B7, Canada; Department of Functional Brain Imaging, National Institutes of Quantum and Radiological Science and Technology, Chiba 263-8555, Japan.
Neuroimage. 2023 May 15;272:120035. doi: 10.1016/j.neuroimage.2023.120035. Epub 2023 Mar 21.
The default-mode network (DMN) is a distributed functional brain system integral for social and higher-order cognition in humans with implications in a myriad of neuropsychological disorders. In this study, we compared the functional architecture of the DMN between humans and marmosets to assess their similarities and differences using joint gradients. This approach permits simultaneous large-scale mapping of functional systems across the cortex of humans and marmosets, revealing evidence of putative homologies between them. In doing so, we find that the DMN architecture of the marmoset exhibits differences along its anterolateral-posterior axis. Specifically, the anterolateral node of the DMN (dorsolateral prefrontal cortex) displayed weak connections and inconsistent connection topographies as compared to its posterior DMN-nodes (posterior cingulate and posterior parietal cortices). We also present evidence that the marmoset medial prefrontal cortex and temporal lobe areas correspond to other macroscopical distributed functional systems that are not part of the DMN. Given the importance of the marmoset as a pre-clinical primate model for higher-order cognitive functioning and the DMN's relevance to cognition, our results suggest that the marmoset may lack the capacity to integrate neural information to subserve cortical dynamics that are necessary for supporting diverse cognitive demands.
默认模式网络（DMN）是一个分布式的大脑功能系统，对人类的社交和高级认知至关重要，对各种神经心理障碍也有影响。在这项研究中，我们比较了人类和狨猴的 DMN 的功能结构，使用联合梯度来评估它们的相似性和差异。这种方法允许在人类和狨猴的大脑皮层上同时进行大规模的功能系统映射，揭示了它们之间可能存在同源性的证据。通过这样做，我们发现狨猴 DMN 的结构在其前后轴上存在差异。具体来说，DMN 的前外侧节点（背外侧前额叶皮层）与后 DMN 节点（后扣带回和后顶叶皮层）相比，显示出较弱的连接和不一致的连接拓扑。我们还提供了证据表明，狨猴的内侧前额叶皮层和颞叶区域与 DMN 无关的其他宏观分布式功能系统相对应。鉴于狨猴作为高级认知功能的临床前灵长类动物模型的重要性，以及 DMN 与认知的相关性，我们的研究结果表明，狨猴可能缺乏整合神经信息的能力，无法支持皮质动态，而皮质动态是支持多样化认知需求所必需的。
