Fann Jesse R, Hart Tessa, Bell Kathleen R, Cole Wesley, Jain Sonia, Raman Rema, Barber Jason, Dikmen Sureyya, Richardson John, Stein Murray B, Temkin Nancy
Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, United States.
Department of Rehabilitation Medicine, University of Washington, Seattle, WA, United States.
Front Neurol. 2025 Jul 29;16:1594748. doi: 10.3389/fneur.2025.1594748. eCollection 2025.
Many active duty service members with mild traumatic brain injury (mTBI) report comorbidities such as depression, anxiety, PTSD, insomnia, and pain. We analyzed data from a prior randomized controlled trial (RCT) to examine the effects of evidence-based treatment modules, delivered by telephone, on the number and symptom burden of five common comorbidities.
356 service members from two military medical centers who had sustained deployment-related mTBI in the preceding 2 years.
Secondary analysis of RCT comparing 6 months of telephone-delivered problem-solving treatment (PST) with comorbidity-specific modules to education only (EO).
Comorbidity burden measured by Patient Health Questionnaire-9, Brief Symptom Inventory-Anxiety, PTSD Checklist, Pittsburgh Sleep Quality Inventory, Rivermead Postconcussion Symptoms Questionnaire (headache item) assessed at baseline and 6 and 12 months.
47% of service members endorsed ≥ 3 comorbidities at baseline. At 6 months, the PST group had significantly fewer comorbidities, greater improvement in depression, anxiety, PTSD, and sleep, but not headache, and higher response/remission rates for depression and sleep, compared to EO. There were no significant group differences at 12 months.
Telephone-delivered PST with comorbidity-specific modules reduces burden of comorbidities after deployment-related mTBI. Research is needed on how to maintain improvements over time.
许多患有轻度创伤性脑损伤(mTBI)的现役军人报告存在合并症,如抑郁症、焦虑症、创伤后应激障碍(PTSD)、失眠和疼痛。我们分析了一项先前随机对照试验(RCT)的数据,以研究通过电话提供的循证治疗模块对五种常见合并症的数量和症状负担的影响。
来自两个军事医疗中心的356名军人,他们在过去2年中遭受了与部署相关的mTBI。
RCT的二次分析,比较为期6个月的通过电话提供的解决问题疗法(PST)与特定合并症模块与仅接受教育(EO)的情况。
通过患者健康问卷-9、简明症状量表-焦虑、PTSD检查表、匹兹堡睡眠质量指数、Rivermead脑震荡后症状问卷(头痛项目)在基线、6个月和12个月时测量合并症负担。
47%的军人在基线时认可存在≥3种合并症。在6个月时,与EO相比,PST组的合并症显著减少,在抑郁症、焦虑症、PTSD和睡眠方面有更大改善,但头痛情况未改善,抑郁症和睡眠的反应/缓解率更高。在12个月时,两组之间没有显著差异。
通过电话提供的带有特定合并症模块的PST可减轻与部署相关的mTBI后的合并症负担。需要研究如何随着时间推移维持改善效果。