Li Kexun, Lu Simiao, Mao Jie, Han Yongtao, Peng Lin, Leng Xuefeng
Department of Thoracic Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China (Sichuan Cancer Hospital), Chengdu, China.
Department of Thoracic Surgery I, Key Laboratory of Lung Cancer of Yunnan Province, Yunnan Cancer Hospital, The Third Affiliated Hospital of Kunming Medical University (Yunnan Cancer Hospital), Kunming, China.
Front Oncol. 2025 Jul 30;15:1621862. doi: 10.3389/fonc.2025.1621862. eCollection 2025.
Esophageal squamous cell carcinoma (ESCC) is a globally prevalent malignancy with distinct regional variations, particularly concentrated in East Asia, including China and Japan. The Union for International Cancer Control/American Joint Committee on Cancer (UICC/AJCC) system offers simplicity but lacks emphasis on anatomical specificity, such as upper mediastinal metastases. Conversely, the Japan Esophageal Society (JES) system provides detailed regional stratification, aiding preoperative planning and tailored therapy, though it demands greater clinical expertise. This review evaluates the current state of pathological lymph node staging systems for ESCC, comparing the UICC/AJCC and JES approaches and exploring emerging trends in China toward station-based staging.
食管鳞状细胞癌（ESCC）是一种在全球范围内普遍存在的恶性肿瘤，具有明显的区域差异，尤其集中在东亚地区，包括中国和日本。国际癌症控制联盟/美国癌症联合委员会（UICC/AJCC）系统操作简单，但缺乏对解剖学特异性的强调，例如上纵隔转移。相反，日本食管癌学会（JES）系统提供了详细的区域分层，有助于术前规划和个性化治疗，尽管它需要更高的临床专业知识。本综述评估了ESCC病理淋巴结分期系统的现状，比较了UICC/AJCC和JES方法，并探讨了中国基于分站式分期的新趋势。
