病例报告：基于纳米孔靶向测序诊断并治愈的脊椎椎间盘炎

Case Report: spondylodiscitis diagnosed and cured based on nanopore targeted sequencing.

作者信息

Zhou Bing, Guo Youfeng, Shen Beiduo, Zhu Ziqi, Yu Bin, Li Gen, Zong Ming, Hu Tao, Wu Desheng

机构信息

Department of Spine Surgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.

Department of Orthopedics, Gaoyou People's Hospital, Gaoyou, China.

出版信息

Front Med (Lausanne). 2025 Jul 30;12:1645609. doi: 10.3389/fmed.2025.1645609. eCollection 2025.

DOI:10.3389/fmed.2025.1645609

PMID:40809431

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12343570/

Abstract

Spondylodiscitis caused by has not been reported yet, making it worthy of further exploration. We closely monitored a patient who experienced worsened low back pain for 1 month and was unable to walk due to severe pain for 1 week. Through thorough examinations, the patient was diagnosed with lumbar disc herniation and a suspected case of spondylodiscitis, necessitating posterior lumbar surgery. All culture results returned negative. However, nanopore targeted sequencing (NTS) identified the presence of . Subsequent administration of appropriate antibiotics resulted in a favorable clinical outcome for the patient.

摘要

由[未提及具体病因]引起的脊椎椎间盘炎尚未见报道，值得进一步探索。我们密切监测了一名患者，该患者下背部疼痛加剧1个月，因剧痛无法行走1周。经过全面检查，该患者被诊断为腰椎间盘突出症，并疑似患有脊椎椎间盘炎，需要进行后路腰椎手术。所有培养结果均为阴性。然而，纳米孔靶向测序（NTS）确定存在[未提及具体物质]。随后给予适当的抗生素治疗，患者获得了良好的临床结果。