Xue Wei, Zhao Yuanyuan, Zhang Gong, Li Zhiyuan, Li Jixin, Fei Xiang
Department of Urology, Shengjing Hospital of China Medical University, Shenyang, China.
Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China.
Front Cell Dev Biol. 2025 Jul 30;13:1549588. doi: 10.3389/fcell.2025.1549588. eCollection 2025.
Malignant tumors of the urinary system, such as kidney cancer, bladder cancer, and prostate cancer, remain a significant challenge despite the various treatment options available. Identifying therapeutic targets for urological tumors is crucial due to the potential for recurrence and metastasis. Recent research has highlighted the importance of RNA modifications in post-transcriptional regulation, impacting various biological functions in urological tumors, including tumorigenesis, progression, metastasis, and drug resistance. However, the specific mechanisms underlying these interactions are not fully understood. This review will focus on exploring the regulatory role of RNA modifications like m1A, m5C, and m7G in urological tumors, shedding light on the pathways and molecular mechanisms involved. This analysis aims to provide new insights for the treatment of urological tumors.
尽管有多种治疗选择，但泌尿系统恶性肿瘤，如肾癌、膀胱癌和前列腺癌，仍然是一个重大挑战。由于存在复发和转移的可能性，确定泌尿系统肿瘤的治疗靶点至关重要。最近的研究强调了RNA修饰在转录后调控中的重要性，其影响泌尿系统肿瘤的各种生物学功能，包括肿瘤发生、进展、转移和耐药性。然而，这些相互作用的具体机制尚未完全了解。本综述将重点探讨m1A、m5C和m7G等RNA修饰在泌尿系统肿瘤中的调控作用，揭示其中涉及的途径和分子机制。该分析旨在为泌尿系统肿瘤的治疗提供新的见解。
