核心岩藻糖基化低分子量激肽原水平在肝纤维化患者中的预测价值：一项前瞻性研究。
Predictive value of core-fucosylated low-molecular-weight kininogen levels in patients with liver fibrosis: A prospective study.
作者信息
Gao Guo-Feng, Yu Jiao, Tong Lin, Jiang Dong
机构信息
Department of Hepatology, Eastern Hepatobiliary Surgery Hospital, Third Affiliated Hospital of Naval Medical University, Shanghai 200433, China.
Department of Laboratory Medicine, Eastern Hepatobiliary Surgery Hospital, Third Affiliated Hospital of Naval Medical University, Shanghai 200433, China.
出版信息
World J Gastroenterol. 2025 Aug 7;31(29):105210. doi: 10.3748/wjg.v31.i29.105210.
BACKGROUND
Core-fucosylated low-molecular-weight kininogen (LMWK-Fc) levels are significantly elevated in patients with liver fibrosis and cirrhosis.
AIM
To assess the value of LMWK-Fc as a diagnostic biomarker for liver fibrosis.
METHODS
Our study included 132 healthy people and 132 patients with liver fibrosis. The LMWK-Fc level was measured based on the principle of chemiluminescence. Fibrosis stage and inflammatory activity were assessed by liver biopsy. Comparative analysis between groups and receiver operating characteristic curve analysis were performed.
RESULTS
LMWK-Fc had an area under the curve of 0.871, which indicates a good level of performance in distinguishing between patients with and without fibrosis. Furthermore, the LMWK-Fc level had a certain correlation with the liver stiffness value, which reached 0.5789.
CONCLUSION
LMWK-Fc could be used as a non-invasive marker of liver fibrosis. Further studies are needed to evaluate the usefulness of this marker.
背景
在肝纤维化和肝硬化患者中，核心岩藻糖基化的低分子量激肽原（LMWK-Fc）水平显著升高。
目的
评估LMWK-Fc作为肝纤维化诊断生物标志物的价值。
方法
我们的研究纳入了132名健康人和132名肝纤维化患者。基于化学发光原理测量LMWK-Fc水平。通过肝活检评估纤维化阶段和炎症活动。进行组间比较分析和受试者工作特征曲线分析。
结果
LMWK-Fc的曲线下面积为0.871，这表明其在区分有无纤维化患者方面表现良好。此外，LMWK-Fc水平与肝脏硬度值有一定相关性，达到0.5789。
结论
LMWK-Fc可作为肝纤维化的非侵入性标志物。需要进一步研究来评估该标志物的实用性。
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