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核心岩藻糖基化低分子量激肽原水平在肝纤维化患者中的预测价值：一项前瞻性研究。

Predictive value of core-fucosylated low-molecular-weight kininogen levels in patients with liver fibrosis: A prospective study.

作者信息

Gao Guo-Feng, Yu Jiao, Tong Lin, Jiang Dong

机构信息

Department of Hepatology, Eastern Hepatobiliary Surgery Hospital, Third Affiliated Hospital of Naval Medical University, Shanghai 200433, China.

Department of Laboratory Medicine, Eastern Hepatobiliary Surgery Hospital, Third Affiliated Hospital of Naval Medical University, Shanghai 200433, China.

出版信息

World J Gastroenterol. 2025 Aug 7;31(29):105210. doi: 10.3748/wjg.v31.i29.105210.

DOI:10.3748/wjg.v31.i29.105210
PMID:40809923
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12344353/
Abstract

BACKGROUND: Core-fucosylated low-molecular-weight kininogen (LMWK-Fc) levels are significantly elevated in patients with liver fibrosis and cirrhosis. AIM: To assess the value of LMWK-Fc as a diagnostic biomarker for liver fibrosis. METHODS: Our study included 132 healthy people and 132 patients with liver fibrosis. The LMWK-Fc level was measured based on the principle of chemiluminescence. Fibrosis stage and inflammatory activity were assessed by liver biopsy. Comparative analysis between groups and receiver operating characteristic curve analysis were performed. RESULTS: LMWK-Fc had an area under the curve of 0.871, which indicates a good level of performance in distinguishing between patients with and without fibrosis. Furthermore, the LMWK-Fc level had a certain correlation with the liver stiffness value, which reached 0.5789. CONCLUSION: LMWK-Fc could be used as a non-invasive marker of liver fibrosis. Further studies are needed to evaluate the usefulness of this marker.

摘要

背景：在肝纤维化和肝硬化患者中，核心岩藻糖基化的低分子量激肽原（LMWK-Fc）水平显著升高。 目的：评估LMWK-Fc作为肝纤维化诊断生物标志物的价值。 方法：我们的研究纳入了132名健康人和132名肝纤维化患者。基于化学发光原理测量LMWK-Fc水平。通过肝活检评估纤维化阶段和炎症活动。进行组间比较分析和受试者工作特征曲线分析。 结果：LMWK-Fc的曲线下面积为0.871，这表明其在区分有无纤维化患者方面表现良好。此外，LMWK-Fc水平与肝脏硬度值有一定相关性，达到0.5789。 结论：LMWK-Fc可作为肝纤维化的非侵入性标志物。需要进一步研究来评估该标志物的实用性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c26e/12344353/ae0f4a1139b1/wjg-31-29-105210-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c26e/12344353/5fc489dfd306/wjg-31-29-105210-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c26e/12344353/287c9a60e47f/wjg-31-29-105210-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c26e/12344353/1909d275c252/wjg-31-29-105210-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c26e/12344353/ae0f4a1139b1/wjg-31-29-105210-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c26e/12344353/5fc489dfd306/wjg-31-29-105210-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c26e/12344353/287c9a60e47f/wjg-31-29-105210-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c26e/12344353/1909d275c252/wjg-31-29-105210-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c26e/12344353/ae0f4a1139b1/wjg-31-29-105210-g004.jpg

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[1]
Predictive value of core-fucosylated low-molecular-weight kininogen levels in patients with liver fibrosis: A prospective study.

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[8]
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[10]
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本文引用的文献

[1]
Human plasma kallikrein: roles in coagulation, fibrinolysis, inflammation pathways, and beyond.

Front Physiol. 2023-8-30

[2]
Hepatic inflammatory responses in liver fibrosis.

Nat Rev Gastroenterol Hepatol. 2023-10

[3]
Treatment of liver fibrosis: Past, current, and future.

World J Hepatol. 2023-6-27

[4]
Prevalence of Liver Steatosis and Fibrosis in the General Population and Various High-Risk Populations: A Nationwide Study With 5.7 Million Adults in China.

Gastroenterology. 2023-10

[5]
Galectin-3 inhibition as a potential therapeutic target in non-alcoholic steatohepatitis liver fibrosis.

World J Hepatol. 2023-2-27

[6]
Potential targeted therapy based on deep insight into the relationship between the pulmonary microbiota and immune regulation in lung fibrosis.

Front Immunol. 2023

[7]
Accurate liquid biopsy for the diagnosis of non-alcoholic steatohepatitis and liver fibrosis.

Gut. 2023-2

[8]
Immune and Metabolic Alterations in Liver Fibrosis: A Disruption of Oxygen Homeostasis?

Front Mol Biosci. 2022-2-3

[9]
Liver Fibrosis-From Mechanisms of Injury to Modulation of Disease.

Front Med (Lausanne). 2022-1-11

[10]
Analysis of site and structure specific core fucosylation in liver cirrhosis using exoglycosidase-assisted data-independent LC-MS/MS.

Sci Rep. 2021-12-2

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