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胃肠外应用羧基麦芽糖铁预防哺乳仔猪缺铁性贫血

The use of parenteral application of ferric carboxymaltose in the prevention of iron deficiency anaemia in suckling piglets.

作者信息

Svoboda Martin, Vasek Jan, Jarkovsky Jiri, Skupien Vojtech, Vitkova Veronika

机构信息

Ruminant and Swine Clinic, Faculty of Veterinary Medicine, University of Veterinary Sciences Brno, Brno, Czech Republic.

Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University Brno, Brno, Czech Republic.

出版信息

Vet Med (Praha). 2025 Jul 25;70(7):242-246. doi: 10.17221/22/2025-VETMED. eCollection 2025 Jul.

Abstract

This study aimed to evaluate the effectiveness of ferric carboxymaltose injection in the prevention of anaemia in suckling piglets. In group A ( = 8), piglets were administered iron in the form of iron carboxymaltose complex (Ferinject) at a dose of 200 mg i.m. (neck muscle) at the age of 3 days. In group B ( = 8), piglets were given iron in the form of iron dextran (Ferribion) at a dose of 200 mg i.m. (neck muscle) at the age of 3 days. In group C ( = 8, anaemic control group), iron was not administered until the age of 10 days. During the study, no statistically significant differences were observed in the parameters of red blood cell count or blood plasma iron concentration between the group that received iron carboxymaltase and the group that received iron dextran. The results of haematological and biochemical examinations achieved in our study show that the application of iron carboxymaltase was successful in preventing iron deficiency anaemia in piglets. The results indicate comparable efficacy of iron carboxymaltase and iron dextran.

摘要

本研究旨在评估羧基麦芽糖铁注射液预防哺乳仔猪贫血的有效性。A组(n = 8)仔猪在3日龄时以200 mg的剂量通过肌肉注射(颈部肌肉)给予铁羧基麦芽糖复合物(Ferinject)形式的铁。B组(n = 8)仔猪在3日龄时以200 mg的剂量通过肌肉注射(颈部肌肉)给予右旋糖酐铁(Ferribion)形式的铁。C组(n = 8,贫血对照组)直到10日龄才给予铁。在研究期间,接受羧基麦芽糖铁的组和接受右旋糖酐铁的组之间,在红细胞计数或血浆铁浓度参数方面未观察到统计学上的显著差异。我们研究中获得的血液学和生化检查结果表明,羧基麦芽糖铁的应用成功预防了仔猪缺铁性贫血。结果表明羧基麦芽糖铁和右旋糖酐铁具有相当的疗效。

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本文引用的文献

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The pharmacokinetics and pharmacodynamics of iron preparations.铁制剂的药代动力学和药效学。
Pharmaceutics. 2011 Jan 4;3(1):12-33. doi: 10.3390/pharmaceutics3010012.
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