动态光学相干断层扫描信号的波长和分辨率依赖性的实验与数值研究

Experimental and numerical investigation of wavelength and resolution dependency of dynamic optical coherence tomography signals.

作者信息

Fujimura Shumpei, Abd El-Sadek Ibrahim, Morishita Rion, Makita Shuichi, Furukawa Atsuko, Mukherjee Pradipta, Lim Yiheng, Zhu Lida, Feng Yunake, Seesan Thitiya, Matsusaka Satoshi, Yasuno Yoshiaki

机构信息

Computational Optics Group, University of Tsukuba, Tsukuba, Ibaraki, Japan.

Department of Physics, Faculty of Science, Damietta University, New Damietta City, Damietta, Egypt.

出版信息

Biomed Opt Express. 2025 Jul 7;16(8):3084-3104. doi: 10.1364/BOE.564030. eCollection 2025 Aug 1.

Abstract

The wavelength and system-resolution dependencies of dynamic optical coherence tomography (DOCT) are investigated experimentally and numerically. Experimental investigations demonstrate significant wavelength dependency for the DOCT values but no marked resolution dependency. Numerical simulations were performed using diffusion, random-ballistic motion, and mono-directional flow-based motion models. Diffusion and random-ballistic motion-based simulations show significant wavelength dependency. Additionally, these simulations revealed a small but certain resolution dependency. Mono-directional flow simulations did not show wavelength dependency but did demonstrate resolution dependency. The DOCT value is sensitive to both tissue dynamics and the OCT system specification. These effects should be considered when interpreting DOCT images.

摘要

对动态光学相干断层扫描(DOCT)的波长和系统分辨率依赖性进行了实验和数值研究。实验研究表明,DOCT值对波长有显著依赖性,但对分辨率没有明显依赖性。使用基于扩散、随机弹道运动和单向流动的运动模型进行了数值模拟。基于扩散和随机弹道运动的模拟显示出显著的波长依赖性。此外,这些模拟还揭示了微小但确定的分辨率依赖性。单向流动模拟未显示波长依赖性,但显示出分辨率依赖性。DOCT值对组织动力学和OCT系统规格都很敏感。在解释DOCT图像时应考虑这些影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4823/12339306/24d3eeee171f/boe-16-8-3084-g001.jpg

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