Experimental and numerical investigation of wavelength and resolution dependency of dynamic optical coherence tomography signals.

The wavelength and system-resolution dependencies of dynamic optical coherence tomography (DOCT) are investigated experimentally and numerically. Experimental investigations demonstrate significant wavelength dependency for the DOCT values but no marked resolution dependency. Numerical simulations were performed using diffusion, random-ballistic motion, and mono-directional flow-based motion models. Diffusion and random-ballistic motion-based simulations show significant wavelength dependency. Additionally, these simulations revealed a small but certain resolution dependency. Mono-directional flow simulations did not show wavelength dependency but did demonstrate resolution dependency. The DOCT value is sensitive to both tissue dynamics and the OCT system specification. These effects should be considered when interpreting DOCT images.