颅电刺激对围绝经期女性认知功能的影响：随机对照研究
Effect of cranial electro-stimulation on cognition in perimenopausal women: randomized control study.
作者信息
Thakur Naveeta, Sharma Nidhi, Kaur Simranjeet, Kumar Parveen, Kapri Preeti, Negi Priyanka
机构信息
Department of Neurological Physiotherapy, Maharishi Markandeshwar Institute of Physiotherapy and Rehabilitation, Maharishi Markandeshwar (Deemed to be University), Mullana (Ambala), Haryana, India.
Department of Musculoskeletal Physiotherapy, Maharishi Markandeshwar Institute of Physiotherapy and Rehabilitation, Maharishi Markandeshwar (Deemed to be University), Mullana (Ambala), Haryana, India.
出版信息
Climacteric. 2025 Aug 14:1-6. doi: 10.1080/13697137.2025.2530444.
OBJECTIVE
The aim of this study was to investigate the efficacy of cranial electrotherapy stimulation (CES) on cognition among perimenopausal women.
METHODS
The pretest-post-test randomized controlled trial was conducted between April 2024 and January 2025. Forty-six perimenopausal women, aged 40-55 years, were randomized into two groups: active CES ( = 23) or sham CES ( = 23). Participants were blinded to the study. Both groups received 30-min sessions, 4 days a week for 4 weeks. The participants were assessed at baseline and at the end of 4 weeks of intervention using the Montreal Cognitive Assessment (MoCA) scale.
RESULTS
Demographic and baseline characteristics depicted a normal distribution for both groups, except for MoCA ( < 0.05). Within-group analyses of both groups demonstrated significant differences for MoCA (active CES, = 0.001; sham CES, = 0.002) with large effect size ≥ 0.5. Between-group analyses of MoCA showed no significant difference with = 0.212 and small effect size ≤ 0.3. The time and group interaction effect showed significant improvement with = 0.001.
CONCLUSIONS
CES has the potential to enhance cognitive function in perimenopausal women. Additionally, no adverse events related to the study were reported.
目的
本研究旨在探讨经颅电刺激疗法（CES）对围绝经期女性认知功能的疗效。
方法
于2024年4月至2025年1月进行了前后测随机对照试验。46名年龄在40 - 55岁的围绝经期女性被随机分为两组：活性CES组（n = 23）和假CES组（n = 23）。参与者对研究不知情。两组均接受每周4天、每次30分钟、共4周的治疗。在基线期以及干预4周结束时，使用蒙特利尔认知评估量表（MoCA）对参与者进行评估。
结果
除MoCA外（P < 0.05），两组的人口统计学和基线特征呈正态分布。两组的组内分析均显示MoCA有显著差异（活性CES组，P = 0.001；假CES组，P = 0.002），效应量较大≥ 0.5。MoCA的组间分析显示无显著差异，P = 0.212，效应量较小≤ 0.3。时间和组间交互效应显示有显著改善，P = 0.001。
结论
CES有增强围绝经期女性认知功能的潜力。此外，未报告与该研究相关的不良事件。
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