Miskowiak J, Andersen B, Stadil F, Fahrenkrug J
Regul Pept. 1985 Nov 7;12(3):231-6. doi: 10.1016/0167-0115(85)90064-3.
Plasma concentrations of pancreatic polypeptide (PP) and vasoactive intestinal polypeptide (VIP) were measured after a meal consisting of 11 ml meat extract and 40 ml of 20% soya oil in 11 patients before and 3 months after gastroplasty for morbid obesity. Gastroplasty results in a small proximal pouch with a narrow stoma allowing delayed emptying into the distal pouch, and consequently postprandial distension of the proximal pouch. Postprandial plasma PP increased significantly (P less than 0.01) independent of gastroplasty. PP is therefore not involved in the early satiety after gastroplasty. Postprandial plasma VIP increased significantly from fasting levels both before and after gastroplasty (P less than 0.05). Only 10 min after a meal, the median value of VIP was significantly higher after than before gastroplasty (P less than 0.02) and may be caused by distension of the proximal pouch.
在11例病态肥胖患者接受胃成形术之前和术后3个月，测量了他们在摄入由11毫升肉提取物和40毫升20%大豆油组成的餐后血浆中胰多肽（PP）和血管活性肠肽（VIP）的浓度。胃成形术会形成一个小的近端胃囊，其开口狭窄，导致排空延迟进入远端胃囊，从而引起近端胃囊的餐后扩张。餐后血浆PP显著增加（P<0.01），与胃成形术无关。因此，PP不参与胃成形术后的早期饱腹感。胃成形术前后餐后血浆VIP均较空腹水平显著升高（P<0.05）。进食后仅10分钟，VIP的中位数在术后就显著高于术前（P<0.02），这可能是由近端胃囊扩张引起的。
