拉丁裔儿童前瞻性出生队列中的婴儿期体重增加与代谢功能障碍相关脂肪性肝病（MASLD）
Weight gain in infancy and metabolic dysfunction-associated steatotic liver disease (MASLD) in a prospective birth cohort of Latino children.
作者信息
Maxwell Sarah L, Price Jennifer C, Perito Emily R, Rosenthal Philip, Wojcicki Janet M
机构信息
Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology, and Nutrition, University of California, 550 16th street, 4th Floor, San Francisco, CA, 94143, USA.
Department of Medicine, Division of Gastroenterology, University of California, San Francisco, USA.
出版信息
Matern Health Neonatol Perinatol. 2025 Aug 15;11(1):25. doi: 10.1186/s40748-025-00225-8.
BACKGROUND
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease among U.S. children. Early weight trajectories correlate with obesity, cardiometabolic syndrome, and MASLD in children born small for gestational age.
METHODS
We evaluated whether increases in weight-for-age (WAZ) score from 0 to 6 months of life, are associated with MASLD in middle childhood, in two prospective birth cohorts of healthy Latino children (n = 136).
RESULTS
After adjusting for confounders, increases in WAZ score from 0 to 6 months of age were associated with a higher risk for MASLD in middle childhood (OR 1.54 95% CI, 1.01-2.36; p = 0.046).
CONCLUSIONS
In a prospective study of Latino children, increases in WAZ score from 0 to 6 months were associated with increased risk of MASLD in mid-childhood. This could inform early screening and counseling for MASLD.
背景
代谢功能障碍相关脂肪性肝病（MASLD）是美国儿童中最常见的慢性肝病。对于小于胎龄儿出生的儿童，早期体重轨迹与肥胖、心脏代谢综合征和MASLD相关。
方法
我们在两个健康拉丁裔儿童的前瞻性出生队列（n = 136）中评估了0至6个月龄时年龄别体重（WAZ）评分的增加是否与儿童中期的MASLD相关。
结果
在调整混杂因素后，0至6个月龄时WAZ评分的增加与儿童中期患MASLD的风险较高相关（OR 1.54，95%CI，1.01 - 2.36；p = 0.046）。
结论
在一项针对拉丁裔儿童的前瞻性研究中，0至6个月时WAZ评分的增加与儿童中期患MASLD的风险增加相关。这可为MASLD的早期筛查和咨询提供依据。
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