Darbinian T M, Papin A A, Vagina M A, Petrov O V
Farmakol Toksikol. 1979 Nov-Dec;42(6):592-7.
Phenazepam was compared to diazepam in a double-blind study made in 32 patients. The drugs were administered by month in doses of 0.0025 mg/kg and 0.005 mg/kg. respectively 1--2 days before surgery with the use of general anesthesia. Anxiety assessed by means of the brain evoked potential test and by a clinical test according to Gologorsky's scale reduced 2 hours following both phenazepam and diazepam administration. Phenazepam elicited a more pronounced and more lasting tranquilizing effect as compared to that of diazepam. Phenazepam was concluded to be a powerful anxiolytic and sedative agent recommended for premedication before surgical interventions.
在一项针对32名患者的双盲研究中，对芬那西泮和地西泮进行了比较。在全身麻醉手术前1至2天，每月分别以0.0025毫克/千克和0.005毫克/千克的剂量给药这两种药物。通过脑诱发电位测试和根据戈洛戈尔斯基量表进行的临床测试评估的焦虑，在服用芬那西泮和地西泮后2小时均有所减轻。与地西泮相比，芬那西泮产生了更显著、更持久的镇静作用。得出结论，芬那西泮是一种强效抗焦虑和镇静剂，推荐用于手术干预前的术前用药。
