F-florzolotau正电子发射断层扫描在认知障碍诊断和治疗决策中的作用。

Role of F-florzolotau PET in diagnostic and therapeutic decision-making for cognitive impairment.

作者信息

Wang Jun, Wang Zi-Yi, Chen Shu-Fen, Wang Rong-Ze, Chen Ke-Liang, Lu Jia-Ying, Xin Jia-Wei, Huang Yu-Yuan, Wang Ming-Yu, Xie Fang, Cheng Wei, Yen Tzu-Chen, Wischik Claude M, Cui Mei, Zuo Chuan-Tao, Zhao Qian-Hua, Wang Yan-Jiang, Yu Jin-Tai

机构信息

Department of Neurology and National Center for Neurological Disorders, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai, China.

Department of Neurology and Center for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, China.

出版信息

Alzheimers Dement. 2025 Aug;21(8):e70563. doi: 10.1002/alz.70563.

DOI:10.1002/alz.70563

PMID:40819956

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12358240/

Abstract

INTRODUCTION

The novel positron emission tomography (PET) tracer, F-florzolotau, enables in vivo visualization of tau pathology.

METHODS

We evaluated the diagnostic performance of disease-specific spatial patterns of F-florzolotau PET imaging by visual read for tauopathies and its added value in diagnostic and therapeutic decision-making in 1277 participants with cognitive complaints.

RESULTS

The disease-specific spatial patterns of F-florzolotau PET imaging demonstrated high diagnostic accuracy in differentiating various tauopathies, with 96.0% for Alzheimer's disease, 94.4% for frontotemporal lobe degeneration, 93.7% for progressive supranuclear palsy, and 97.5% for corticobasal degeneration. Added to a standard diagnostic workup, F-florzolotau PET reading led to diagnostic revisions for 247 participants (19.3%), increased diagnostic confidence from 68.6% to 81.3%, and resulted in medication changes for 284 participants (22.2%).

DISCUSSION

Our data advocate for the strategic implementation of F-florzolotau PET in memory clinics, offering transformative potential for patient care and management.

HIGHLIGHTS

F-Florzolotau PET imaging presented disease-specific spatial patterns for different tauopathies. The disease-specific spatial patterns of F-florzolotau positron emission tomography (PET) imaging exhibited high diagnostic accuracy in differentiating various tauopathies. Integration of F-florzolotau PET imaging modality to a standard diagnostic workup significantly enhanced diagnostic confidence, enabled diagnostic revisions, and informed adjustments to treatment strategies.

摘要

引言

新型正电子发射断层扫描（PET）示踪剂F-florzolotau能够在体内可视化tau蛋白病变。

方法

我们通过视觉解读评估了F-florzolotau PET成像的疾病特异性空间模式在tau蛋白病诊断中的性能，以及其在1277名有认知症状参与者的诊断和治疗决策中的附加价值。

结果

F-florzolotau PET成像的疾病特异性空间模式在区分各种tau蛋白病方面显示出高诊断准确性，阿尔茨海默病为96.0%，额颞叶痴呆为94.4%，进行性核上性麻痹为93.7%，皮质基底节变性为97.5%。在标准诊断检查基础上，F-florzolotau PET解读导致247名参与者（19.3%）的诊断修正，诊断信心从68.6%提高到81.3%，并导致284名参与者（22.2%）的用药改变。

讨论

我们的数据支持在记忆门诊中战略性地实施F-florzolotau PET，为患者护理和管理提供变革潜力。

要点

F-Florzolotau PET成像呈现了不同tau蛋白病的疾病特异性空间模式。F-florzolotau正电子发射断层扫描（PET）成像的疾病特异性空间模式在区分各种tau蛋白病方面表现出高诊断准确性。将F-florzolotau PET成像模式整合到标准诊断检查中显著提高了诊断信心，实现了诊断修正，并为治疗策略调整提供了依据。