Wu Meng-Hao, Wei Ling, Li Pei, Zhang Chi, Wang Yan, Guo Quan-Zhou
Department of Operation and Anaesthesia, Xingtai Central Hospital Xingtai 054000, Hebei, China.
Am J Transl Res. 2025 Jul 15;17(7):5214-5220. doi: 10.62347/UMOA1809. eCollection 2025.
Chronic kidney disease (CKD) can progress to an advanced stage, eventually developing into end-stage renal disease (ESRD). Currently, the only effective treatment for ESRD is renal replacement therapy, with maintenance hemodialysis (MHD) being the most widely used modality, accounting for approximately 90% of all dialysis patients. However, the perioperative risk of surgery and anesthesia in these patients remains extremely high. Therefore, careful selection of surgical timing, appropriate anesthetic agents, and suitable anesthetic techniques is crucial. This report describes the anesthetic management of a 62-year-old female patient who had been hospitalized in the orthopedic ward for nine months due to left toe necrosis secondary to diabetic foot, in the setting of CKD requiring MHD. She was later admitted to Xingtai Central Hospital with progressive necrosis involving the left second and third toes and extending to the dorsum and plantar aspect of the foot. The patient was diagnosed with left-sided diabetic foot necrosis, stage 5 CKD, type 2 diabetes mellitus with multiple complications, grade 3 hypertension (high risk), and chronic hepatitis B infection. An elective transtibial (below-knee) amputation of the left lower limb was planned. Anesthesia was provided using color Doppler ultrasound-guided left iliac fascia block, left lateral femoral cutaneous nerve block, and left sciatic nerve block. Intravenous isoproterenol infusion, dexmedetomidine, and dizocine injection were administered for intraoperative sedation and analgesia. The patient's intraoperative vital signs remained stable. Postoperatively, the patient was awake, in good general condition, and was transferred to the ward with regular monitoring.
慢性肾脏病(CKD)可进展至晚期,最终发展为终末期肾病(ESRD)。目前,ESRD唯一有效的治疗方法是肾脏替代治疗,维持性血液透析(MHD)是应用最广泛的方式,约占所有透析患者的90%。然而,这些患者手术和麻醉的围手术期风险仍然极高。因此,仔细选择手术时机、合适的麻醉药物和恰当的麻醉技术至关重要。本报告描述了一名62岁女性患者的麻醉管理情况,该患者因糖尿病足继发左足趾坏死在骨科病房住院9个月,患有需要MHD的CKD。她后来因左第二和第三足趾渐进性坏死并蔓延至足背和足底而入住邢台市中心医院。该患者被诊断为左侧糖尿病足坏死、CKD 5期、2型糖尿病伴多种并发症、3级高血压(高危)和慢性乙型肝炎感染。计划对左下肢进行择期经胫骨(膝下)截肢术。采用彩色多普勒超声引导下左髂筋膜阻滞、左股外侧皮神经阻滞和左坐骨神经阻滞进行麻醉。术中静脉输注异丙肾上腺素、右美托咪定和地佐辛注射液用于镇静和镇痛。患者术中生命体征保持稳定。术后,患者清醒,一般情况良好,经定期监测后转入病房。