Xiang Shanshan, Wu Zhengjun, Yao Yipeng
Guangxi Key Laboratory of Rare and Endangered Animal Ecology, Guangxi Normal University Guilin 541006, Guangxi, China.
Guangxi Technological College of Machinery and Electricity Nanning 530007, Guangxi, China.
Am J Transl Res. 2025 Jul 15;17(7):5453-5464. doi: 10.62347/EVJG5641. eCollection 2025.
To evaluate the efficacy of therapeutic hypothermia in enhancing cognitive and motor outcomes six months post-TBI.
A retrospective cohort analysis was conducted on data from the Medical Information Mart for Intensive Care (MIMIC) database. A total of 259 TBI patients were divided into a Routine group (n = 135) and a Hypothermia Therapy group (n = 124). The hypothermia group received core temperature reduction to 33-35°C for 3-5 days. Cognitive and motor functions were assessed using the Functional Independence Measure (FIM), Fugl-Meyer Motor Assessment (FMA), and Glasgow Coma Scale (GCS) at baseline and six months post-treatment. Patients' satisfaction was also evaluated.
After six months of treatment, the hypothermia group showed significantly higher FIM motor scores, and FIM cognitive scores than the routine group (P < 0.01). A higher proportion of patients in the hypothermia group achieved mild impairment on the FMA assessment than in the routine group (P = 0.003). The hypothermia group demonstrated better consciousness levels (P = 0.006) and reported significantly higher patient satisfaction rate (P = 0.004).
Hypothermia therapy significantly improved cognitive and motor recovery in TBI patients, enhanced consciousness levels, and increased patient satisfaction rate.
评估治疗性低温对创伤性脑损伤（TBI）后六个月认知和运动结局的改善效果。
对重症监护医学信息集市（MIMIC）数据库中的数据进行回顾性队列分析。总共259例TBI患者被分为常规组（n = 135）和低温治疗组（n = 124）。低温治疗组的核心体温降至33 - 35°C，持续3 - 5天。在基线和治疗后六个月，使用功能独立性测量（FIM）、Fugl - Meyer运动评估（FMA）和格拉斯哥昏迷量表（GCS）评估认知和运动功能。同时评估患者的满意度。
治疗六个月后，低温治疗组的FIM运动评分和FIM认知评分显著高于常规组（P < 0.01）。低温治疗组在FMA评估中达到轻度损伤的患者比例高于常规组（P = 0.003）。低温治疗组的意识水平更好（P = 0.006），患者满意度显著更高（P = 0.004）。
低温治疗显著改善了TBI患者的认知和运动恢复，提高了意识水平，并提高了患者满意度。
